Bone Abstracts

Ostearthritis (OA) is most common form of joint disease and one of the leading causes of disability and pain in elderly people worldwide. Historically, OA has been considered a non-inflammatory disease, but more recently studies revealed that inflammation is a risk factor associated with both progression of cartilage destruction and signs and symptoms of disease. Mean platelet volume (MPV), red blood cell distribution width (RDW), platelet distribution width (PDW), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and RDW-to-platelet ratio (RPR) can be obtained with a basic hemogram test. These parameters have been investigated as a predictor of inflammatory process in many diseases, their roles in OA is unclear. The aim of the present study was to investigate the diagnostic value of routine hematological parameters on OA and explore their clinical significance. The study included 118 patients with osteoarthritis and 145 age and gender matched healthy individuals. Medical records, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), White Blood Cell (WBC) count, NLR, platelet count (PLT), PDW, RDW, RPR, PLR and MPV levels were retrospectively recorded from patient files. There were no significant differences in WBC, RDW, PLT, RPR levels between two groups (all P > 0,05). NLR and PLR values were significantly higher in OA group compared to control group (all p<0.001). RBC, MPV and PDW values were significantly lower in OA than control group (all P<0.001). Patients with OA had significantly higher CRP and ESR values compared to control group (P=0,020 and P=0,011, respectively). In addition, ESR was positively correlated with CRP and negatively correlated with RBC, MPV and PDW levels in OA patients. Also, CRP was negatively correlated with RBC and MPV levels in OA patients. Our study showed that hematological inflammatory markers might be useful parameters that can be used in patients with OA.