Bone Abstracts

Bone is a highly dynamic tissue that is constantly dismantled and rebuilt throughout life by the coordinated and balanced activities of matrix-resorbing osteoclasts, bone-forming osteoblasts and matrix-embedded osteocytes. This system is governed by interconnected signaling pathways, transcription factors, secreted regulators, genetic determinants and epigenetic cues including non-coding RNAs. Canonical Wnt signaling is among the most influential pathways regulating tissue dev...

Epidemiological studies have found that patients with Type 2 Diabetes Mellitus (T2D) have a higher incidence of fragility fractures relative to non-diabetic individuals. Given the substantial morbidity, mortality and costs that emanate from T2D-related fractures, proper recognition of T2D individuals at increased fracture risk is indispensable. Although fracture risk in type 2 diabetics is routinely assessed with WHO-FRAX scores or DXA these methods show limitations. This high...

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