Bone Abstracts

Background: Non-surgical hypoparathyroidism (NS-HypoPT) and pseudohypoparathyroidism (Ps-HypoPT) are both rare diseases, with a prevalence of 2/100.000 and 1/100.000, respectively.

Studies on Quality of Life, QoL, are sparse, but studies have shown an increased risk of fatigue and depression.

Methods: Using the Danish version of SF36v2 and WHO-5 Well Being Index, we investigated the physical and mental QoL among patients with NS-HypoPT (n=10) and Ps-HypoPT (n=9). Furthermore we investigated the physical activity using the validated questionnaire, Physical Activity Scale, PAS, measuring time spend sleeping, working and leisure during 24 h.

Results: The SF36v2 shows a significantly reduced score among patients with NS-HypoPT compared to a norm-based population at the subdomains: physical functioning, PF (45.6±10.4), role-physical, RP (43.7±11.6), general health, GH (43.0±11.9), vitality, VT (45.1±13.7) and role-emotional, RE (44.6±12.9, all P<0.05). In contrast, patients with Ps-HypoPT did not differ from norm-based controls at any of the domains, and the physical and mental component score did not differ between any of the patient groups and controls. However, NS-HypoPT have a significantly reduced physical component score compared with Ps-HypoPT (P<0.05).

The overall WHO-5 Well Being Index score was 52 (IQR 36–72) in the NS-HypoPT group (min 16; max 84), whereas it was 64 (IQR 50–77) in the Ps-HypoPT group (min 44; max 80). A score below 28 indicates depression (N_NS-HypoPT=3; N_Ps-HypoPT=0), whereas a score between 28–50 suggesting poor emotional well-being (N_NS-HypoPT=7; N_Ps-HypoPT=2). The rest have a score above 50 suggesting a state of well-being.

The median 24 h metabolic equivalent, MET-value, was 40.6 (IQR 35.4–57.3) in the NS-HypoPT group and 37.8 (IQR 33.9–44.5) in the Ps-HypoPT group (P=0.31).

Conclusion: Patients with NS-HypoPT have a significantly reduced QoL compared with both a norm-based population and patients with Ps-HypoPT. On the other hand, patients with Ps-hypoPT do not seem to suffer from impaired QoL.