ECTS2016 Poster Presentations Osteoporosis: treatment (40 abstracts)
1Department of Medical Research, Pharmaserve Lilly SACI, Athens, Greece; 2Private Office, Veria, Greece; 3Private Office, Trikala, Greece; 43rd Orthopedics University Clinic, Papageorgiou General Hospital, Thessaloniki, Greece.
Scope: Extended Forsteo Observational Study (ExFOS), a multinational, non-interventional, prospective, observational study aims to evaluate fracture outcomes, back pain (BP), compliance and health-related Quality of Life (QoL) in osteoporotic patients prescribed teriparatide (TPTD). We present treatment outcomes for patients (male or female) treated for up to 24 months in Greece.
Methods: Of the 440 patients enrolled in the study 416 (mean age 69.9±9.7 years) have performed at least one active treatment post-baseline visit. These were predominantly women (92.1%), at postmenopausal stage (99.7%). Self-reported parameters of health perception have been recorded throughout the study through validated questionnaires (EQ-5D). We report the observed percent and mean responses.
Results: Seventeen (4.1%) patients had an incident clinical fracture during follow-up. Adherence: 80% of subjects used the treatment through month 23; 45% continued use through month 24. BMD numerically increased in all sites. Indicatively, Lumbar BMD T-score (mean (S.D.)) increased from −3.39 (0.73) at baseline to −2.36 (0.63) at study end. BP history the last year before enrollment was reported by 88.9%. During treatment, all self-reported variables improved. Examples of BP frequency (% of patients with BP fairly often or almost daily) and BP severity (% with moderate-severe BP), EQ-5D Visual Analogue Scale (VAS) score and EQ-5D mobility (% reporting some or extreme problems) are depicted below.
Baseline | 3 m | 6 m | 12 m | 18 m | 24 m | |
BP frequency (%) | 68.2 | 33.5 | 22.6 | 14.1 | 17 | 11.6 |
BP severity (%) | 76.2 | 50.4 | 32.8 | 20.9 | 22.2 | 18.6 |
EQ-5D VAS | 57.4 | 66.2 | 71.3 | 75.4 | 76.7 | 83 |
EQ-5D Mobility (%) | 57.9 | 39.0 | 29.9 | 22.5 | 17.7 | 16.2 |
Conclusions: Use of TPTD remains high almost throughout the follow-up. A decrease at month 24 may be due to prescribing (24 months/26 cartridges) particularities. Patients experience improvement in BP and QoL. Fracture rate was low. Results should be interpreted in the context of an observational study.