Bone Abstracts

Introduction: This study aims to assess 25-hydroxyvitamin D—25(OH)D—status in perimenopausal women to analyze its relationships with serum PTH levels and bone mineral density (BMD).

Methods: A total of 102 individuals who visited to climacteric clinic in Sanggye paik hospital participated in the study. Serum 25(OH)D and intact parathyroid hormone (PTH) were measured. BMD was determined by dual x-ray absorptiometry (DXA) at lumbar spine, femoral neck, and total hip.

Results: Serum 25(OH)D levels were below 20 ng/ml in 73% of participants. There was a significant seasonal difference in mean serum 25(OH)D, with higher levels in summer–autumn. In Pearson correlation, serum 25(OH)D was negatively correlated with PTH (r=−0.219, P=0.03), not with the age and BMD. In ANOVA, BMD was significantly low in the women older than 60 years (P=0.000). Level of 25(OH)D and PTH was not different among different age groups. No difference was shown in level of PTH and BMD among different 25(OH)D groups.

Conclusions: Vitamin D insufficiency is very common among in Korean perimenopausal women. Serum 25(OH)D is negatively correlated with PTH (r=−0.219, P=0.03). BMD can decrease with age, although the level of 25(OH)D was not decreased.