ECTS2016 Poster Presentations Nutrition (13 abstracts)
Caffeine at moderate dose did not affect the skeletal system of rats with streptozotocin-induced metabolic disorders
Joanna Folwarczna 1 , Aleksandra Janas 1 , Urszula Cegiela 1 , Maria Pytlik 1 , Leszek Sliwinski 1 , Magdalena Matejczyk 1 , Anna Nowacka 1 , Karolina Rudy 1 , Zora Krivošíková 2 , Kornélia Štefíková 2 & Martin Gajdoš 2
1Department of Pharmacology, School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia, Katowice, Sosnowiec, Poland; 2Department of Clinical and Experimental Pharmacotherapy, Medical Faculty, Slovak Medical University, Bratislava, Slovakia.
Diabetes leads to development of osteoporosis. Experimental type 1 diabetes may be induced by a single dose of streptozotocin (STZ), and nicotinamide (NA) administered 15 min before STZ dose-dependently protects against the STZ action. Coffee drinking, apart of its health benefits, is taken into consideration as an osteoporosis risk factor. Data from human and experimental studies on coffee and caffeine effects on the skeletal system are inconsistent. For example, although other experimental reports indicated unfavorable effects of caffeine, we previously reported beneficial skeletal effects of its moderate dose in ovariectomized rats (Mol Nutr Food Res, 2013). The present study was performed to investigate effects of moderate-dose caffeine on diabetes-induced disorders in the rat skeletal system.
Effects of caffeine (20 mg/kg p.o. daily for 4 weeks) were investigated in 3-month-old female Wistar rats (n=8–10 per group), which, 2 weeks before the start of caffeine administration, were administered STZ (60 mg/kg i.p.) alone or STZ after NA (230 mg/kg i.p.). Bone mass, mineral density (BMD), histomorphometric parameters, and mechanical properties of the tibial metaphysis, femoral diaphysis and femoral neck were examined.
STZ induced diabetes, with increased bone resorption and decreased bone formation. Decreases in BMD and worsening of cancellous bone mechanical properties (the tibial metaphysis) were demonstrated. Although STZ after NA induced slight glycemia increases in first days of the experiment only, mechanical properties of cancellous bone were worsened and vertebral BMD was decreased. Administration of caffeine did not significantly affect bone histomorphometric parameters, mineralization and mechanical properties in STZ and STZ/NA-treated rats.
In conclusion, results of the present study indicate that moderate-dose caffeine did not exert damaging effect on the skeletal system of rats with streptozotocin-induced metabolic disorders. The results contribute to the notion that caffeine may not be the main culprit responsible for unfavorable skeletal effects of coffee drinking.
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