Bone Abstracts

We have shown that the bisphosphonate pamidronate (P) given to children <10d post-burn prevents resorptive bone loss and muscle protein breakdown. We have also shown in vitro that Ca modulates the inflammatory response by altering mononuclear cell chemokine production. We hypothesized that P affects muscle protein breakdown by altering cytokine or chemokine concentration directly or indirectly by lowering blood ionized (i) Ca. We retrospectively analysed biomarker...

Background: An inadequate intake of nutrients, low levels of physical activity, and chronic diseases contribute to reduce muscle mass and physical performance in elderly. WHO reported that number of individuals aged ≥60 years will triple in 2050, with the sub-population aged >85 years that will grow faster than the others. Market of nutraceuticals and dietary supplements is growing in Italy, in particular aimed to improve health in elderly. Objective of this scoping ...

Background: Post-menopausal women generally present reduced serum levels of vitamin D, reduced VDR expression in skeletal muscle cells, and a gradual loss of muscle mass and muscle function. The relationship between serum 25-hydroxyvitamin D [25(OH)D3] levels and muscle strength has been extensively investigated, even though there is no agreement in literature. Therefore, aim of our study was to evaluate the effects of vitamin D on 25(OH)D3 levels, muscle strength, and physica...

Although it is well established, that quality of life improves in patients after lung transplantation (LTx), severe musculoskeletal complications may develop. The aim of this study was to evaluate differences in the muscle markers Myostatin and Follistatin and the bone markers Dickkopf-1 (DKK1), Sclerostin (SOST) and Periostin between LuTx recipients and healthy controls. From 38 LTx patients blood samples were taken when discharged from hospital (LTx1) and 6-9 months after di...

The aim of the study was to evaluate the role of vitamin D and exercises in correction of age-related skeletal muscle changes in postmenopausal women.Materials and methods: 38 postmenopausal women aged 53–82 years (mean age – 67.00±7.08 yrs) were examined. The women were divided into the following groups: A – control group (n=10), B – women who took an individually-targeted vitamin D therapy (n=11), C – wom...

Study design: Prospective study.Objectives: The risk factors correlated with actual falls were assessed in patients with lumbar spinal stenosis.Materials and methods: In 201 patients (M:F 65:136) with symptomatic lumbar spinal stenosis, falls history within recent one year was investigated. The factors which were expected correlation with actual falls were evaluated together. Blood chemistry was performed to evaluate serum Vitamin ...

Sports specific training may have different impact on bone outcomes, and adolescence is a key period to optimize bone health. The aim was to examine hip differences on bone outcomes between osteogenic (football) and non-osteogenic (swimming and cycling) sports in adolescent males.One hundred twenty one males (13.1±0.1 years) volunteered to partake in this study that received ethics approval from the UK National Research Ethics Service. Participants ...

The exposition of shift workers to light at night supresses the melatonin (ME) production. ME supression may contribute to the development of osteoporosis, which can be prevented and treated by resistance exercise (RE). This study evaluated the effect of ME release supression by pineal gland (pinealectomy) and the RE on rats tibiae morphology, mineral quantification and mechanical parameters. The project was approved by the local ethics committee (protocol 2014-00939). Fourty ...

Introduction: Hypertrophy of ligamentum flavum (LF) induces narrowing of spinal canal which develops neurogenic claudication. Several mechanisms of LF hypertrophy have been suggested. Among them inflammatory cytokine play a crucial role in LF hypertrophy by increasing collagen synthesis. Cyclooxygenase-2 (COX-2) pathway shares inflammatory reaction from infection and arthritis. Selective COX-2 inhibitor (COX-2si) might modulates collagen synthesis via suppressing inflammatory ...

High fat diet (HFD), obesity, and physical inactivity characterize the modern lifestyle. This can lead to coronary heart diseases and type 2 diabetes mellitus. Recent studies have shown that these conditions frequently are associated with poor bone quality. However, the molecular mechanisms are poorly understood. To analyze the effect of HFD and exercise (EX) on bone homeostasis, we fed 6 week-old C57BL/6 mice a high fat (60% fat) or standard chow diet for 10 weeks (10-20 mice...

Objective: To investigate the relationship of frailty with vitamin D in community dwelling elderly women.Materials and methods: A retrospective cross-sectional study was performed on women over 60 years who were not using vitamin D supplementations. Frailty status was defined using Fried’s criteria: weakness, low walking speed, low physical activity, weight loss, exhaustion. Participants were classified as robust, prefrail and frail if they scored 0...

Background: Disturbance of systemic phosphate homeostasis is often associated with musculoskeletal dysfunction. Multiple factors related to the underlying condition such as calcium levels and endocrine mechanisms are thought to contribute. Distinct effects of inorganic phosphate itself as well as its main regulator FGF23 by activation of similar pathways have been shown in several cell types. We are not aware of any detailed investigations into their effect on the differentiat...

Interference fit fixation of soft-tissue grafts is in clinical focus to allow anatomic graft fixation which increases stability and graft isometry. Although clinical data show promising results with different screw materials, the issue of biodegradability, handling and stability in the first weeks remain under demand. The purpose of the present study was to investigate anterior cruciate ligament (ACL) reconstruction radiologically, biomechanically and histologically using dire...

Introduction: The significance of sarcopenia and low muscle mass are especially emphasized in these days. Sarcopenia is well known to highly correlate with fragility and increases the risk of falling in the elderly and an important risk factor for disability and mortality. Evidence of inter-relaionship of muscle with bone metabolism is increasing. Therefore we investigated the relationship between BMD and muscle mass among healthy Korean premenopausal women.<p class="abste...