ECTS2016 Poster Presentations Energy metabolism and bone, fat and bone (11 abstracts)
The interrelationship of 25-hydroxyvitamin D and osteocalcin on glycolipid metabolism: a cross-sectional study in type 2 diabetics
Junlei Su 1 , Mingxin Xu 1 , Jie Hao 1 , Zhiyin Zhang 1 , Ni Zhong 1 , Ran Cui 1 , Bei Xu 1 , Feng Li 1 , Tienan Feng 1 , Ge Zhang 2 , Hui Sheng 1 & Shen Qu 1
1Department of Endocrinology and Metabolism, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China; 2Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong, Hong Kong.
Context: As bone metabolic markers, recent studies indicated vitamin D and osteocalcin (OC) were also involved in energy metabolism. While the exact relationship between vitamin D and OC in regulating energy metabolism is unclear. One of the possibilities is that: low vitamin D could lead to secondary hyperparathyroidism and following high bone turnover, which would enhance the quantity of bioactive OC.
Objective: Our aim was to study whether OC mediated the metabolic effect of vitamin D, along with their interaction on glycolipid metabolism in a cross-sectional study.
Method: A total of 701 Chinese type 2 diabetic patients, aged from 27 to 93, were recruited. Spearman correlation and linear regression analysis were performed. OC and OC * 25(OH)D were added to the regressions in order to study the interaction effect.
Results: The inverse associations of 25(OH)D with HbA1c(beta=−0.013, P=0.001), FPG (beta=−0.019, P=0.001), 2hPG (beta=−0.020, P=0.018), TG (beta=−0.005, P=0.021) and positive associations with 2hCP (beta=−0.014, P=0.004), HDL (beta=0.002, P<0.001) and HOMA2-%B (beta=0.250, P=0.003) were independent of PTH and OC in type 2 diabetics. The significant interaction of 25(OH)D and OC on HOMA2-%B (P for interaction=0.0362) were observed in this study.
Conclusion: No evidence suggests that OC mediates the vitamin D metabolic effect in our study. 25(OH)D combining with OC may have greater facilitation to beta-cell function.
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