ECTS2016 Poster Presentations Cancer and bone: basic, translational and clinical (37 abstracts)
Antiproliferative properties of oleuropein in human osteosarcoma cells
Jose M Moran , Olga Leal-Hernandez , Maria L Canal-Macias , Jesus M Lavado-Garcia , Raul Roncero-Martin , Ignacio Aliaga & Juan D Pedrera-Zamorano
Metabolic Bone Diseases Research Group, University of Extremadura, Caceres, Spain.
Background: Cancer is one of the leading causes of death worldwide. Natural products have been regarded as important sources of potential chemotherapeutic agents. In this study, we evaluated the antiproliferative activity of oleuropein, an olive oil compound traditionally found in the Mediterranean diet.
Design and Methods: The antiproliferative activity on two human osteosarcoma cell lines (MG-63 and Saos2) was evaluated in vitro using the MTT colorimetric methods. The median inhibitory concentration values (IC50) and 95% confidence interval (CI) for oleuropein were established by the weighted Probit method for both cell lines at 24, 48 and 72 h of exposure.
Results: Oleuropein exhibited obvious cytotoxic effects on human osteosarcoma cells in a concentration- and time-dependent manner. Statistical analysis of IC50 by the Probit regression method suggested that oleuropein had similar toxic effects on both cell lines tested (IC50 range from 247.41 to 474.97 μM for MG63 cells and IC50 range from 798.69 to 359.91 μM for Saos2 cells).
Conclusion: This is the first study showing an antiproliferative activity of oleuropein in human osteosarcoma cell lines.
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