ECTS2016 Poster Presentations Bone development/growth and fracture repair (35 abstracts)
Adiponectin prevents orthodontic tooth movement in rats
Sigrid Haugen 1 , Kristin Matre Aasarød 2 , Astrid Kamilla Stunes 2 , Mats Peder Mosti 2 , Tanya Franzen 3 , Vaska Vandevska-Radunovich 3 , Unni Syversen 2 & Janne Reseland 1
1Department of Biomaterials, Institute for Clinical Dentistry, University of Oslo, Oslo, Norway; 2Department of Cancer Research and Molecular Medicine, NTNU, Trondheim, Norway; 3Department of Orthodontics, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.
Adiponectin may play a role in both bone and periodontal remodeling. In this study, the effect of repetitive local administration of human recombinant adiponectin on experimental tooth movement was examined.
The first molar of 24 male Wistar rats was moved mesially by a closed coil spring ligated to the molar and anchored to the incisors in front for 14 days, with adiponectin injections every 3rd day. Amount of tooth movement was examined by feeler gauge and in vivo μCT. Effect of adiponectin injections on bone and periodontal ligaments were examined by histology sections of the right maxilla. Influence on circulating bone markers and cytokines were studied by Luminex and ELISA.
Adiponectin injections caused a significant reduction in tooth movement on day 12 and 14 compared to control. No difference in bone mineralization was identified with μCT. Quantitation of bone volume fraction, demonstrated a reduction in the control group at day 14 whereas the bone volume in the adiponectin was unchanged, the difference, however, was not significant. Adiponectin enhanced the collagen content in the periodontal region compared to control. No significant changes in selected bone and cytokine factors in plasma were observed between in adiponectin-treated compared to control rats.
Adiponectin prevents orthodontic tooth movement in rats. This anchorage effect may be taken advantage of in clinical settings, though further studies are required.
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Bone Abstracts
ISSN 2052-1219 (online)
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