Bone Abstracts

Tendinopathy is a painful condition that occurs in and around tendons in response to overuse. The role of inflammation and inflammatory mediators in the development or progression of tendinopathy have been investigated in many studies, but it is still uncertain and controversial. Mean platelet volume (MPV), red blood cell distribution width (RDW), platelet distribution width (PDW), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and RDW-to-platelet ratio (RPR) may indicate the systemic inflammatory response associated with many diseases. In this retrospective study, we aimed to evaluate the relationship between routine hematological indices and tendinopathy. The study consisted of 65 tendinopathy patients and 77 age and gender matched healthy individuals. Age, sex, white blood cell (WBC) count, NLR, platelet count, MPV, PDW, RDW, RPR, PLR, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were retrospectively recorded from patient files. There were no significant differences in WBC, RDW, RPR and CRP levels between two groups (all P > 0,05). Platelet values, NLR levels and PLR values of patients with tendinopathy were significantly higher than control subjects (P=0,046, P=0.009, P=0.008 respectively). MPV values, RBC values and PDW values were found to be significantly lower in patients group (all P<0.001). Patients with tendinopathy had higher ESR values compared to control group (P=0,046). Furthermore, ESR was positively correlated with CRP, PLT and PCT and negatively correlated with RDW and RPR in tendinopathy patients. Also, CRP was positively correlated with WBC and PLT and negatively correlated with RDW, MPV, PDW and RPR in tendinopathy patients. Results of our study have shown that hematologic parameters can be useful prognostic biomarkers in tendinopathy. Further large-scale prospective studies are required to confirm these findings and demonstrate the prognostic significance of these values.