ECTS2016 Poster Presentations Arthritis and other joint diseases: translational and clinical (11 abstracts)
A clinical study to examine thresholds of joint space width and joint space area for identification of knee osteoarthritis
Richard Ljuhar 1 , Benjamin Norman 1 , Davul Ljuhar 1 , Tobias Haftner 1 , Jiri Hladuvka 3 , Mary Bui Thi Mai 3 , Helena Canhão 4 , Ana Maria Rodrigues 4 , Nelia Gouveia 4 , Jaime Branco 4 , Stefan Nehrer 5 , Astrid Fahrleitner-Pammer 2 & Hans-Peter Dimai 2
1Braincon Technologies, Vienna, Austria; 2Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria; 3VRVis Research Competence Center, Vienna, Austria; 4Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal; 5Center for Regenerative Medicine & Orthopedics, Danube University, Krems, Austria.
Objective: Osteoarthritis (OA) is a degenerative, slowly developing joint disease. Although clinical indications of OA can vary among different definitions there is a general agreement that the disease is associated with cartilage narrowing. However, there is no general consensus about the threshold below which the joint space width (JSW)/joint space area (JSA) can be certain indicators for the state of OA. Therefore this study evaluates these limits to reveal quantitative information about indicators of OA.
Methods: The study included 226 standardized 2D knee radiographs from 101 cases and 125 controls. All images were acquired in PA direction and standardized positions. The minimum JSW and JSA were calculated by using the i3a software. Three physicians assessed by using the Kellgren & Lawrence Score and assigned the images to either a Case or Control group. A knee was assigned to the Case group, if at least two physicians assessed it as being affected by OA.
Results: Considering the minimum JSW, an odds ratio of 5.63 (CI: 3.17–9.99) with an accuracy of 70.35% and a sensitivity of 70.30% can be obtained. Every subject that has a minimum JSW below 3.4 mm belongs to Cases. With respect to the minimum JSA, the odds ratio is 3.60 with an accuracy of 65.49% and a sensitivity of 65.35%. Results also show that every subject with a minimum JSA below 50 mm2 is being considered to have OA.
Conclusion: Based on this study it can be concluded that a JSW below 3.4 mm and a JSA below 50 mm2 at the knee joint are strong indicators for OA. Thus, for clinical assessments it is suggested to consider these threshold values for diagnostic purposes. In further studies, symptomatic knee OA should be incorporated to verify whether minimum JSWs and JSAs can also be linked to symptomatic knee pain.
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