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43rd Annual European Calcified Tissue Society Congress

Rome, Italy
14 May 2016 - 17 May 2016

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ba0005lb1 | (1) | ECTS2016

All-trans retinoic acid can antagonize osteoblastogenesis induced by different BMPs irrespective of their dimerization types and dose- efficiencies

Liu Yi , Guo Jing , Lin Zhen , Wismeijer Daniel , Lu Haiping , Wu Gang

Introduction: Alcoholism can result in a compromised regenerative capacity of bone and delayed osteointegration of dental implants. One of the mechanisms is that the thereby overdosed all-trans retinoic acid (ATRA), a main metabolite of alcohol, can significantly inhibit osteoblastogenesis. Bone morphogenetic proteins, potent osteinductive growth factors, can be applied to promote osteogenesis. We previously showed that heterodimerized BMP2/7 could promote osteoblastogenesis i...
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ba0005lb2 | (1) | ECTS2016

Rat femoral neck research: an alternative method of histological sections

Crivelini Marcelo Macedo , Araujo de Oliveira Erica , Kiill Noelle Egidia Watanabe , Dornelles Rita Cassia Menegati , Bedran de Castro Joao Cesar , Garcez de Mello Wagner

Histomorphometry is often adopted as a methodological approach in research of femoral bone structure. However, it is common do not describe technical details of procedure especially on the steps of macroscopy, paraffin embedding and microtomy. So we propose a simplified, reliable and reproducible method of histological processing for intertrochanteric region and femoral neck of mice, to ensure the achievement of tissue sections with similar structures, cell populations and his...
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ba0005lb3 | (1) | ECTS2016

Peripheral quantitative computed tomography measures contribute to the understanding of bone fragility in low-trauma fracture patients

Jiang Hongyuan , Yates Christopher , Gorelik Alexandra , Kale Ashwini , Song Qichun , Wark John D

Background and aims: Dual energy X-ray absorptiometry (DXA) as currently utilised has limitations in identifying patients with osteoporosis and predicting fractures, since most low-trauma fracture (LTF) patients have osteopenia not osteoporosis based on DXA assessment. We aimed to express peripheral quantitative computed tomography (pQCT) variables of patients with low-trauma fracture as T-scores by using T-score scales obtained from healthy young women, and ...
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ba0005lb4 | (1) | ECTS2016

Bone mineral density in anorexia nervosa patients

Djurovic Marina Nikolic , Jemuovic Zvezdana , Miljic Dragana , Vasovic Olga , Jankovic Dragana , Petakov Milan

Anorexia nervosa (AN) is an eating disorder characterized by severe undernutrition. Osteopenia is a frequent, often persistent complication of anorexia nervosa (AN) in adolescent girls and occurs during a critical time of bone development. To determine the impact of chronic undernutrition on bone mineral accrual we measured bone mineral density by dual energy x-ray absorptiometry, bone metabolism markers and leptin levels in AN patients (n=19, age 22.67±1.9 years...
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ba0005lb5 | (1) | ECTS2016

Posterior migration of fusion cages in degenerative lumbar disease treated with anterior lumbar interbody fusion

Shih Cheng-Min , Lee Cheng-Hung

Introduction: Most reports focused on clinical advantages of intervertebral cages; only a few studies reviewed the complications. As one of the major complications, cage migrating into vertebral body or spinal canal may result in disastrous consequence. Multiple risk factors may result in cage migration, such as geometric design of cage, surgical technique, the bone quality and post-operative protection. The following is a presentation of nine patients with migrated cage.<...
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ba0005lb6 | (1) | ECTS2016

Sclerostin blockade and zoledronic acid improve bone mass and strength in mice with exogenous hyperthyroidism

Tsourdi Elena , Lademann Franziska , Ominsky Michael , Hofbauer Lorenz , Rauner Martina

Hyperthyroidism in mice is associated with a low bone mass, an increased bone turnover and high serum levels of sclerostin, a potent Wnt inhibitor. Here, we explored the effects of either reducing bone turnover with bisphosphonates or increasing bone formation with neutralizing sclerostin antibodies (Scl-Ab) on bone mass and estimated strength in hyperthyroid mice.Twelve-week-old C57BL/6 male mice were rendered hyperthyroid by adding L-thy...
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ba0005lb7 | (1) | ECTS2016

Dose bisphosphonate-based anti-osteoporosis medication affect osteoporotic spinal fracture healing?

Ha Kee-Yong , Kim Young-Hoon , Kim Sang-Il

Introduction: The purpose of this prospective study is to investigate whether bisphosphonate-based anti-osteoporosis medication affects fracture healing and clinical outcomes of conservatively treated osteoporotic spinal fractures (OSFs).Method: A total of 105 patients who were diagnosed with acute OSFs were prospectively enrolled. According to their previous medication history, the patients were allocated into group I (n=39, no history of bisph...
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ba0005lb8 | (1) | ECTS2016

Bone texture modifications during bone regeneration and osteocyte cell-signaling changes in response to treatment with Teriparatide

Smargiassi Alberto , Checchi Marta , Cavani Francesco , Ferretti Marzia , Palumbo Carla

Teriparatide is the active fragment (1–34) of the endogenous human parathyroid hormone (PTH). Studies showed that chronic administration of PTH results in decreased bone mass while intermittent exposure to PTH activates osteoblast bone deposition. Most of the structural studies published so far about the effect of Teriparatide focused their attention on the amount of newly-deposed bone without investigating the quality of the newly-formed bone tissue; moreover, most of th...
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ba0005lb9 | (1) | ECTS2016

First X-linked form of osteogenesis imperfecta, caused by mutations in MBTPS2, demonstrates a fundamental role for regulated intramembrane proteolysis in normal bone formation

Lindert Uschi , Cabral Wayne , Ausavarat Surasawadee , Tongkobpetch Siraprapa , Ludin Katja , Barnes Aileen , Yeetong Patra , Weis Maryann , Krabichler Birgit , Makareeva Elena , Janecke Andreas , Leikin Sergey , Rothlisberger Benno , Rohrback Marianne , Kennerknecht Ingo , Eyre David , Suphapeetiporn Kanya , Giunta Cecilia , Marini Joan , Shotelersuk Vorasuk

Osteogenesis imperfecta (OI) is a heritable bone dysplasia with collagen-related defects. Dominantly inherited OI is caused by structural defects in type I collagen or IFITM5, while recessive forms are caused by deficiency of proteins that interact with collagen for modification, folding or cross-linking. We have identified the first X-linked form of OI, caused by a defect in regulated intramembrane proteolysis (RIP). One type of RIP involves sequential cleavage of regulatory ...
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ba0005lb10 | (1) | ECTS2016

Abstract unavailable....
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ba0005lb11 | (1) | ECTS2016

25(OH)D3 half-life is not influenced by vitamin D supplementation dose

Schoenmakers Inez , Assar Shima , Aspray Terry , Prentice Ann , Jones Kerry

There is wide variation in the dose-response to oral vitamin D and the increment in plasma 25(OH)D decreases per unit vitamin D given. We hypothesised that this is related to increased 25(OH)D catabolism as reflected in 25OHD half-life (25(OH)D3 t1/2).Design: 25(OH)D3 t1/2 was measured with a stable isotope (SI) technique in older (70y+) men and women in the UK during winter before (<...
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ba0005lb12 | (1) | ECTS2016

The role of Creld2 in skeletal development and homeostasis

Dennis Ella , Capulli Mattia , Teti Anna , Pirog Katarzyna , Briggs Michael

Cysteine-rich with EGF like domains 2 (Creld2) has recently been identified as an endoplasmic reticulum (ER) stress inducible gene in the context of skeletal dysplasia caused by mutant protein accumulating in the ER eliciting an unfolded protein response (UPR). Creld2 was originally implicated in ER stress following the treatment of Neuro2α cells with thapsigargin. Furthermore, the promoter of Creld2 contains an ER stress activating transcription factor ...
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ba0005lb13 | (1) | ECTS2016

High-fat diet can accelerate the bone loss process of ovariectomized rats?

Yanagihara Gabriela , Shimano Roberta , Tida Jacqueline , Macedo Ana Paula , Shimanno Antonio Carlos

After many years of study, researchers show that obesity can harm the bones. It is not known whether the increased fat mass can accelerate the process of bone loss. The aim of this study was to evaluate whether high-fat diet accelerates the process of bone loss in ovariectomized rats. This study was approved by the Ethics Committee of our Institution (188/2013). 40 female wistars rats with body mass of 60 g were used in this study. They were equally divided into four experimen...
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ba0005lb14 | (1) | ECTS2016

Mechanical properties of rat tibia bone defect after treatment with latex membrane

Carlos Bruna Leonel , Yanagihara Gabriela Rezende , Yamanaka Jessica Suzuki , Shimano Antonio Carlos

In recent years, latex membrane synthesized from natural latex extracted from rubber tree Hevea brasiliensis, has been studied as an important biomaterial to assist in tissue regeneration process, since it has ability to induce neovascularization and tissue proliferation, and is a low-cost and easy material handling. The aim of this study was to evaluate mechanical properties of bones after treatment with natural latex membrane in bone defects created in the tibiae of...
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ba0005lb15 | (1) | ECTS2016

siRNA-mediated Noggin inhibition enhances osteogenesis and mineralization

Ghadakzadeh Saber , Mekhail Mina , Hamdy Reggie , Tabrizian Maryam

Non-unions and critical size defects (CSD) are major orthopedic challenges. The gold standard for CSD treatment, bone grafting, is associated with several morbidities. Growth factors such as bone morphogenetic proteins (BMPs) have been utilized in clinic. Nevertheless, huge doses are required for therapeutic effects. Endogenous BMP antagonists, such as Noggin, could be inhibited using small interfering RNA (siRNA) to increase the bioavailability of BMPs and accelerate bone hea...
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ba0005lb16 | (1) | ECTS2016

Proposal for a full-body suspension model for osteopenia induction

Penoni Alvaro , Yanagihara Gabriela , Tida Jacqueline , Brancaleon Brigida , Issa Joao Paulo , Shimano Antonio

Introduction: Osteopenia and osteoporosis are osteometabolics disorders characterized by decreased bone mineral density (BMD) with deterioration of bone microarchitecture. Since the beginning of the space age, there was a growing interest in trying to reproduce on Earth an environment that could simulate the effects of microgravity to induce bone, a state of osteopenia. The aim of this study was to present a new osteopenia induction model through the full body suspension.<...
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ba0005lb17 | (1) | ECTS2016

Efficacy of the therapeutic compliance in the brittle bone disease and in the elderly people frailty

D'Amico Ferdinando

Objective: The study evaluated the efficacy of the therapeutic compliance in brittle bone disease applied to frail elderly people affected by osteoporosis and in treatment with Denosumab.Methods: We studied people ≥75; 43 women (mean age 83±3) and 14 men (mean age 85±3), all suffering from femoral osteoporosis T-score <−4. In 34 women and 6 men, we discovered 1–2 vertebral fractures. They have been treated with Den...
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ba0005lb18 | (1) | ECTS2016

Evidence that CD146 positive bone marrow stromal cells in bone metastases have an inhibitory role in regulating tumor growth

Tietgen Maren , Damm Timo , Lenk Lennart , Desel Christine , Sebens Susanne , Gluer Claus-C , Tiwari Sanjay

The concept of the vicious cycle of bone metastases emphasizes the cross-talk between osteoclasts, osteoblasts and tumor cells, but the role of bone marrow stromal cells (BMSCs) is not well delineated. BMSCs comprise of a fibroblast-like cell population which adhere to culture flask and have an ability to differentiate into osteoblasts, adipocytes and chondrocytes. They express a panel of cell surface antigens which includes CD105, CD73, CD90, CD106, and CD146. In this study w...
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