ICCBH2015 Poster Presentations (1) (201 abstracts)
Comparing two scanning protocols for high-resolution peripheral quantitative computed tomography for bone quality assessment in young subjects
Ka Yee Cheuk 1, , Jiajun Zhang 1, , Echo Tsang 1, , Fiona Yu 1, , Vivian Hung 1, , Elisa M S Tam 1, , Tsz Ping Lam 1, , Simon K M Lee 3 , Bobby K W Ng 1, & Jack C Y Cheng 1,
1Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong, Hong Kong; 2Joint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing University, Hong Kong, Hong Kong; 3Lee Hysan Clinical Research Laboratories, The Chinese University of Hong Kong, Hong Kong, Hong Kong.
Objectives: High resolution peripheral quantitative computed tomography (HR-pQCT) was used to evaluate bone quality and volumetric bone mineral density (vBMD). However, manufacturers only provide a standard protocol for adult but not for growing subjects. The aim of this study was to investigate the difference on measurement between two different HR-pQCT scanning protocols in adolescence with unfused growth plate.
Methods: 27 boys and 26 girls aged 13–16 were recruited. Their non-dominant distal radius was scanned by two HR-pQCT scanning protocols consecutively. In Protocol 1, distance between corresponding reference line and first slice of region of interest (ROI) was set at 5 mm, whereas in Protocol 2, that distance between corresponding reference line and first slice of ROI was 4% of the radius length. Paired t-test or Wilcoxon signed rank test was preformed to compare the result of measurement.
Results: Total area was lower, cortical area was higher and trabecular area was lower in Protocol 1 as compared to Protocol 2 for both boys and girls. In boys, only trabecular vBMD and trabecular bone volume fraction showed no difference between the two protocols (P=0.78 and 0.76). Among all parameters, the difference in cortical thickness between the two protocols was greatest in boys (% diff=20.6%, P<0.001). In contrast, only total vBMD and cortical perimeter showed significant differences between the two protocols in girls (% diff=3.6% and −1.47%, P=0.032 and 0.05).
Conclusion: Differences in HR-pQCT measurement with Protocol 1 and 2 in both boys and girls stemmed from the difference in location of ROI between the two protocols with the ROI in Protocol 1 being more distal than that in Protocol 2. Greater discrepancy noted between the two protocols in boys was probably due to less overlapping of ROI between the two protocols and that boys have a larger change on bone morphology at the distal radius when compared with girls. Further investigations are warranted to elucidate which protocol gives a more valid evaluation of bone density and bone quality and caution must be exercised when comparing studies that involve different protocols of measurements.
Disclosure: The authors declared no competing interests.
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