Relationship of lipid parameters and insulin resistance with bone health in South Korean adolescents

Do-Hoon Kim; Sang-Woon Park; Dong-Wook Jung; Su-Jung Yoon; Kyungdo Han; Yong-Gyu Park; Jun-Seok Choi; Jong-Eun Lee; Jung-Eun Sang; Ga-Eun Nam; Yeo-Joon Yoon

doi:10.1530/boneabs.4.P200

Objectives: To prevent future osteoporosis, it is important to identify factors that affect bone health in adolescents as well as adults. This study aimed to examine the relationship between lipid profiles and insulin resistance and BMC in Korean adolescent population.

Methods: Data from 706 boys and 621 girls who participated in the Korea National Health and Nutrition Examination Survey from 2008 to 2011 were analyzed. Lipid profiles were measured, and homeostasis model assessment of insulin resistance (HOMA-IR) was calculated to assess insulin resistance. BMC was measured at the total femur, femur neck, and lumbar spine by using whole-body dual-energy x-ray absorptiometry.

Results: Triglyceride level and HOMA-IR were negatively correlated with BMC at all 3 sites in boys. In girls, triglyceride level showed a negative correlation with BMC at the femur neck and lumbar spine, and HOMA-IR was negatively associated with BMC only at the femur neck. The adjusted odds ratios (ORs) for the highest BMC tertile group at the total femur and lumbar spine were significantly decreased as triglyceride level increased and the ORs for the highest BMC tertile group at lumbar spine was decreased according to increasing total cholesterol level in boys. In girls, the ORs for the highest BMC tertile group at all 3 sites were also decreased as triglyceride level increased. The value of BMC at femur neck and total femur was negatively associated with HOMA-IR only in boys.

Table 3 Adjusted ORs (CIs) for highest tertile group of BMC according to lipid parameters and insulin resistance.
	Boys			Girls
	Femur neck	Total femur	Lumbar spine	Femur neck	Total femur	Lumbar spine
TC	0.97 (0.93, 1.01)	0.99 (0.95, 1.04)	0.94 (0.88, 0.997)	0.92 (0.87, 0.97)	0.95 (0.90, 1.01)	0.97 (0.93, 1.02)
LDL-C	0.98 (0.93, 1.03)	1.01 (0.96, 1.06)	0.95 (0.89, 1.02)	0.94 (0.89, 1.00)	0.95 (0.89, 1.02)	0.99 (0.93, 1.05)
HDL-C	1.05 (0.92, 1.19)	1.11 (0.98, 1.24)	1.01 (0.89, 1.15)	0.96 (0.83, 1.11)	1.03 (0.90, 1.18)	0.96 (0.86, 1.08)
TG^a	0.74 (0.47, 1.18)	0.56 (0.35, 0.897)	0.52 (0.34, 0.8)	0.33 (0.17, 0.65)	0.55 (0.32, 0.96)	0.57 (0.35, 0.92)
HOMA-IR^a	0.49 (0.27, 0.88)	0.42 (0.21,0.83)	0.74 (0.39, 1.38)	0.64 (0.27, 1.52)	0.77 (0.39, 1.51)	0.61 (0.28. 1.32)
BMC, bone mineral content; HOMA-IR, homeostasis model assessment of insulin resistance; OR, odd ratio; TC, total cholesterol; TG, triglyceride. Values were obtained by using a multi van able logistic regression analysis after adjustment for age, weight, height, daily energy and calcium intake, alcohol intake, smoking status, physical activity, serum 25-hydroxyvitamin D3, and menarche (in girls).
aLog transformation was performedfor analyses.

Conclusion: BMC was inversely associated with triglyceride and HOMA-IR in boys and triglyceride in girls.

Disclosure: The authors declared no competing interests.

Bone Abstracts

P200