ICCBH2015 Poster Presentations (1) (201 abstracts)
Relationship of IGF1 and bone parameters in 7--16 year old apparently healthy Indian children
Neha Kajale 1 , Veena Ekbote 1 , Sonal Palande 1 , Dhanashri Shilvant 1 , Rubina Mandlik 1 , Vaman Khadilkar 1 , Zulf Mughal 2 & Anuradha Khadilkar 1
1Growth and Endocrine Unit, Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India; 2Department of Paediatric Endocrinology, Royal Manchester Children’s Hospital, Manchester, UK.
Objective: GH through IGF1 plays an important role in both bone growth and mineralization. This cross-sectional study was carried out to evaluate the relationship between serum IGF1 concentrations and dual energy X-ray (DXA) measured total body less head (TB) bone area (BA), lean body mass (LBM) and bone mineral content (BMC).
Methods: One hundred and nineteen children (B=70, age =7.3–15.6 years) were studied for their anthropometric parameters by standard methods and bone and body composition by DXA. Their fasting serum IGF1 concentrations were assessed by ELISA. IGF1 concentrations were converted to Z-scores. Bone and body composition parameters were also converted to Z-scores.
Results: Mean age of the boys and girls was similar (11.5±1.8 years). Mean serum IGF1 concentrations and IGF1 Z-scores were similar (P>0.1) between boys and girls and were of the order of 302.3±140.0, −1.37±1.11 respectively. The TBLBM for age and TBBA for age Z-scores were significantly greater (P<0.05) in children with IGF1 Z-score >−2 than children with IGF Z=score <−2. (TBLBM Z-score: 0.34±0.8, −0.4±0.9; TBBA Z-score: 0.64±0.9, −0.25±1.0). The mean total body bone mineral content for age Z-scores were 0.24±0.9 and −0.26±0.9 in children with above and below −2 of IGF Z-score (P>0.1).
Conclusion: Serum IGF1 concentrations were more strongly associated with BA and LBM (Fig. 1), suggesting that its effect on bone is greater with respect to periosteal bone acquisition and through its effect on muscle mass.
Disclosure: The authors declared no competing interests.
Figure 1 Mean TBBA, LBM and TBBMC Z-scores in children with IGFIZ-score below and above-2.
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