ECTS2014 Poster Presentations Arthritis and other joint diseases: translational and clinical (15 abstracts)
Nasonova Research Institute of Rheumatology, Moscow, Russia.
There is discussed an interrelation of BMD, progressing of erosive and destructive changes in hands and feet with development of vertebral deformations in rheumatoid arthritis (RA).
The aim: To receive data on bone mineral density (BMD), erosive and destructive changes in hands and feet and vertebral deformations in patients with RA.
Materials/methods: In this research, it was included 106 women, with RA, age 2369 years. In all patients BMD was assessed by dual energy X-ray absorptiometry (DXA) on one Hologic «DiscoveryA» at three sites (lumbar spine (L1L4), hip neck (HN) and distal part of forearm (DF) of nondominant hand) and was performed an X-ray morphometric analysis of vertebral bodies deformations with Genant method. The assessment of radiological signs of RA progressing was used with Sharp/van der Heijde method in 67 years. The Statistica 6.0 was used in the statistic analysis.
Results: The mean age of patients included in this research was 52.2±10.3 years, the mean age at the time of the beginning of RA was 36.9±12.1 of years, the mean duration of RA was 13.3±11.2 years. The positive rheumatoid factor was in 77 (73%) patients. 50 (47%) patients received glucocorticoids (GC). The index of erosions amount was 38.5±51.2 points, the amount of narrowed cracks 88.6±41.1 points, the total Sharp/van der Heijde score was 126.5±84.9 points. Mean BMD at L1L4 was 0.911±0.147 g/cm2, at HN 0.705±0.117 g/cm2, at DF 0.463±0.09 g/cm2. Osteoporosis (OP) at L1L4 was revealed in 14 (15%), at HN in 10 (11%), at DF in 32 (35%) patients. Osteopenia (Op) at L1L4 was in 45 (48%), at HN in 48 (53%), at DF in 36 (39%) patients. Normal BMD was revealed at L1L4 in 35 (37%), at HN in 33 (36%), at DF in 24 (26%) patients. The vertebral deformations were revealed in 24 (22%) patients. The index of vertebral deformations at thoracic site of spine was 0.77±0.08, at lumbar site 0.79±0.06.
Conclusions: Despite the young age, patients included in research had a long duration of disease. OP at least in one department of a skeleton was revealed at a third of patients, vertebral deformations at every fifth.