Quantitative ultrasonometry of the phalanges in post-menopausal women with type 2 diabetes mellitus: the first results of a 3-year longitudinal study

Cosimo Neglia; Nadia Agnello; Alberto Argentiero; Giovanna Chitano; Elena Gianicolo; Roberta Ciccarese; Antonella Vigilanza; Valentina Denetto; Giuseppe Quarta; Alessandra Della Rosa; Antonio Caretto; Alessandro Distante; Prisco Piscitelli

doi:10.1530/boneabs.3.PP277

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Bone Abstracts (2014) 3 PP277 | DOI: 10.1530/boneabs.3.PP277

ECTS2014 Poster Presentations Osteoporosis: pathophysiology and epidemiology (38 abstracts)

Quantitative ultrasonometry of the phalanges in post-menopausal women with type 2 diabetes mellitus: the first results of a 3-year longitudinal study

Cosimo Neglia ^1, , Nadia Agnello ² , Alberto Argentiero ^2, , Giovanna Chitano ² , Elena Gianicolo ² , Roberta Ciccarese ² , Antonella Vigilanza ² , Valentina Denetto ² , Giuseppe Quarta ² , Alessandra Della Rosa ² , Antonio Caretto ³ , Alessandro Distante ² & Prisco Piscitelli ^1,

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¹University of Salento, Lecce, Italy; ²ISBEM - Istituto Scientifico Biomedico Euro Mediterraneo, Brindisi, Italy; ³University of Pisa, Pisa, Italy.

Objectives: Type 2 diabetes mellitus (T2DM) is associated to an higher risk of fractures despite a normal or increased bone mineral density measured by dual-energy X-ray absorptiometry (DXA).

The purpose of this 3-years longitudinal study was to assess the changes of quantitative ultrasound (QUS) parameters in a group of postmenopausal women with T2DM and in healthy controls.

Materials and method: The analyses were performed on a group of 35 postmenopausal women attending to the OSTEOLAB within the (Prevention of Osteoporosis ad Fracture) PROF project in collaboration with the Health Local Authority of Brindisi. We selected 17 women affected by T2DM and 18 healthy controls aged 55–70 years. Subjects had baseline and 40 months follow-up measurements of phalangeal ultrasonometry, performed using DBM Sonic Bone Profiler 1200 (Igea) as well as information about medical history, current drug therapy and risk factors.

Results: General characteristics and phalangeal QUS measurements in the two groups are reported and show at baseline only ultrasound bone profile index (UBPI) was significantly lower in T2DM group (P<0.05), instead at follow up were significantly lower bone transmission time (BTT) (P<0.01) and amplitude dependent speed of sound (AD-SoS) (P<0.02) in the same group.

During the period of the study we found an increase of BMI in the two groups of 82.3 and 55.7%, respectively in T2DM group and healthy control.

The decrease of BTT and UBPI was significantly higher in T2DM group (P=0.01 and P=0.03 respectively).

Conclusions: Among phalangeal QUS parameters, AD-SoS, usually associated to bone mineral density and the most used predictor parameter of fractures risk in clinical practice not showed difference between baseline and follow-up measurement in both group. Conversely BTT and UBPI, that give information about bone mineral quality, resulted decreased in T2DM subjects suggesting a future role in the clinical practice for the diagnosis of alterations of bone micro-architecture in T2DM subjects.