ECTS2014 Poster Presentations Muscle, physical activity and bone (16 abstracts)
No beneficial effects of vitamin D supplementation in muscle function or quality of life in primary hyperparathyroidism: results from a randomized controlled trial
Lars Rolighed 1 , Lars Rejnmark 2 , Tanja Sikjaer 2 , Lene Heickendorff 3 , Peter Vestergaard 4 , Leif Mosekilde 2 & Peer Christiansen 1
1Department of Surgery P, Aarhus University Hospital, Aarhus C, Denmark; 2Department of Endocrinology and Internal Medicine, THG, Aarhus University Hospital, Aarhus C, Denmark; 3Department of Clinical Biochemistry, NBG, Aarhus University Hospital, Aarhus C, Denmark; 4Department of Endocrinology and Clinical Institute, Aalborg University Hospital, Aalborg, Denmark.
Context: Impairment of muscle function and strength in patients with primary hyperparathyroidism (PHPT) is rarely addressed although decreased muscle function may contribute to increased fracture risk in PHPT.
Objective: We aimed to assess changes in muscle strength, muscle function, postural balance, quality of life (QoL), and well-being during treatment with vitamin D or placebo before and after parathyroidectomy (PTX) in PHPT patients.
Design and setting: Randomized placebo controlled trial at a single center.
Patients: We included 46 PHPT patients, mean age 58 (range 29–77) years and 35 (76%) were women.
Interventions: Daily treatment with 70 μg (2800 IU) cholecalciferol or placebo for 52 weeks. Treatment was administered 26 weeks prior to PTX and continued for 26 weeks after PTX.
Main outcome measures: Changes in QoL and measures of muscle strength and function.
Results: During 26 preoperative weeks of medical treatment, we did not measure any beneficial effects of supplementation with vitamin D compared with placebo regarding QoL, postural balance, muscle strength, or function. In the entire group of patients, we measured marked improvements in QoL, well-being (P<0.01), muscle strength in the knee flexion and extension (P<0.001), and muscle function tests (P<0.01) after surgical cure by PTX. Postural balance improved during standing with eyes closed (P<0.05), whereas patients had a decreased stability with eyes open (P<0.05).
Conclusions: Patients with PHPT and vitamin D insufficiency did not benefit from vitamin D supplementation concerning muscle strength, muscle function, postural balance, or quality of life. Independent of preoperative vitamin D levels, PTX improved these parameters.
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