ECTS2014 Poster Presentations Cancer and bone: basic, translational and clinical (11 abstracts)
1Kyung Hee University Hospital, Seoul, Republic of Korea; 2National Cancer Center, Ilsan, Republic of Korea.
Pagets disease of bone is a condition where the process of bone remodeling is disrupted; Its primary event is an increased bone resorption followed by a subsequent reactive bone formation. The disease is most common in central Europe, the United Kingdom, Australia, and New Zealand. It is also found, though with lower incidence, in southern Europe, Scandinavia, and the United States. It is extremely rare in East Asian countries, especially in Korea, Japan, China, the Middle East, India and Africa. Through the English literature, none of the Pagets sarcoma were reported from these East Asian countries. We recently experienced a case of Pagets sarcoma from Korean male subject. The patient is 74-year-old male suffering several years with Pagets disease affecting both ilium, pubis and ischium. Recently he was noticed huge right hip mass and the mass were excised. Histologically it was high grade sarcoma and the ischium showed high grade osteoblastic osteosarcoma. We did gene analysis for Q16STM1 and TNFRSF11A from the sarcoma area. No Q16STM1 gene mutation was found however, in TNFRSF11A gene, there was exon 6 mutation 192 codon cytosine to thymine, which means alanine to valine mutation.