ECTS2014 Poster Presentations Arthritis and other joint diseases: translational and clinical (15 abstracts)
Mutual associations among diseases causing disability, such as musculoskeletal diseases, metabolic syndrome components, and mild cognitive impairment: a 3-year follow-up of the ROAD study
Noriko Yoshimura 1 , Shigeyuki Muraki 1 , Hiroyuki Oka 1 , Sakae Tanaka 2 , Hiroshi Kawaguchi 3 , Kozo Nakamura 4 & Toru Akune 1
122nd Century Medical and Research Center, The University of Tokyo, Tokyo, Japan; 2Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 3Tokyo Kosei Nenkin Hospital, Tokyo, Japan; 4National Rehabilitation Center for Persons with Disabilities, Saitama, Japan.
To assess the associations among diseases causing disability requiring support, including i) musculoskeletal diseases (knee osteoarthritis (KOA), lumbar spondylosis (LS), and osteoporosis (OP)); ii) metabolic risk factors for cardiovascular diseases, including overweight (OW), hypertension (HT), dyslipidaemia (DL), and impaired glucose tolerance (IGT); and iii) mild cognitive impairment (MCI).
Among 1690 participants (596 men and 1094 women) at the baseline, 1384 individuals (81.9%; 466 men and 918 women) repeated the first follow-up in 2008 and completed blood, mini-mental state, and radiographic examinations, and measurement of bone mineral density. Logistic regression analysis was performed using occurrence or non-occurrence of the above-mentioned risk factors as the objective variable, after adjusting for confounders and presence or absence of the above-mentioned risk factors as explanatory variables.
Risk of KOA occurrence increased significantly by presence of HT, IGT, and MCI (P=0.018, 0.042, and 0.043 respectively). Occurrence of OP of the femoral neck was inversely associated with OW (P=0.007). OW was influenced significantly by presence of KOA and MCI (P=0.001 for both). Risk of HT occurrence increased by presence of KOA and OW (P=0.030 and 0.021 respectively). IGT occurrence was influenced significantly by presence of OW (P=0.009). In contrast, occurrence of LS or DL was not influenced by factors of metabolic syndrome or musculoskeletal diseases. In addition, occurrence of MCI was not influenced by any other factor.
We concluded that some musculoskeletal diseases, metabolic risk factors, and cognitive impairment were clarified to be associated with each other.
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