Searchable abstracts of presentations at key conferences on calcified tissues
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European Calcified Tissue Society Congress 2014

Prague, Czech Republic
17 May 2014 - 20 May 2014

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European Calcified Tissue Society Annual Congress, 17 - 20 May 2014; Prague, Czech Republic

Workshops

The interactive extracellular matrix

ba0003w5.2 | The interactive extracellular matrix | ECTS2014

Collagenous matrix and cell behaviour

Kadler Karl

During the last 12 months we have worked on 2 projects that I will talk about at the ECTS 2014 conference. The first is our work on collagen fibril formation at the cell surface, using tendon as a model tissue. We have shown that the transport of newly-formed fibrils at the plasma membrane requires non-muscle myosin II. The second is that tendon is a peripheral clock tissue. We have shown that the tendons in mice lacking circadian rhythm have abnormal collagen fibril assembly ...

ba0003w5.3 | The interactive extracellular matrix | ECTS2014

Skeletal genetic diseases involving matrix proteins

Briggs Michael

Skeletal diseases are a large and diverse group of rare monogenic phenotypes and there are more than 450 unique and well-characterised chondrodysplasia phenotypes that range in severity from relatively mild to severe and lethal forms. Studying these genetically tractable chondrodysplasia phenotypes provides insight into disease pathways that may be relevant to the more common and polygenic forms of OA.Pseudoachondroplasia (PSACH) and multiple epiphyseal ...