ECTS2014 Poster Presentations Osteoporosis: treatment (68 abstracts)
Effects of preventive long-term treatment with strontium ranelate and zoledronic acid to ovariectomized rats on bone microstructure
Marta Martín-Fernández 1 , Marina Gómez-Chinchón 1 , David Guede 2 , Jose Ramón Caeiro 3 , Manuel Díaz-Curiel 4 & Concepción De la Piedra 1
1Bioquímica Investigación, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain; 2Trabeculae, Technology Based Firm, Technological Park of Galicia, Ourense, Spain; 3Traumatology and Orthopedic Surgery, University Hospital Complex of Santiago de Compostela, Santiago de Compostela, Spain; 4Internal Medicine, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.
Many pharmacological treatments have been developed in order to prevent or treat postmenopausal osteoporosis. There is not any study in the literature comparing long-term treatments of osteoporosis. The aim of this work was to studythe effects of long-term prevention treatment with zoledronic acid (ZA) and strontium ranelate (SrR) on bone microstructure in ovariectomized rats.
Sixty 6-month-old female Wistar rats were used in this study and divided into four groups: SHAM (n=15), simulated intervention; OVX (n=15), ovariectomized; OVX+ZA (n=15), ovariectomized and treated with ZA (0.08 mg/kg i.v. at the begining of the study); OVX+SrR (n=15) ovariectomized and treated with SrR (0.033 g/kg per day by oral gavage. Treatments started one day after ovariectomy. Eight months later all rats were sacrificed and bone microstructure by microCT scan analysis was performed.
Orchidectomy produced a significant reduction of bone quality, as all the microestructural parameters of the trabecular region showed (BV/TV, BS/TV, Tb.N, Tb.Sp, Tb.Th, Tb.Pf, SMI and Conn.Dn). ZA treatment avoided this bone deterioration, even enhancing microCT parameters with respect to the SHAM group. OVX+SrR group did not show any change in these parameters with respect to the OVX group. Microstructural parameters of the cortical region were not modified in any of the studied groups with respect to the SHAM group.
SrR long-term preventive treatment is no capable of avoid the effects of ovariectomy. Long-term treatment of ovariectomized rats with ZA prevented effects of ovariectomy on bone microstructure, even improving bone quality of healthy group.
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