ECTS2014 Poster Presentations Osteoporosis: treatment (68 abstracts)
Effect of daily intake of milk enriched with a high dose of vitamin D in healthy postmenopausal women: preliminary results from a randomized, controlled and double-blind nutritional trial (The EFICALCIO study)
Manuel Muñoz-Torres 1 , Rebeca Reyes-Garcia 1, , Antonia Garcia-Martin 1, , Santiago Palacios 4 , Nancy Salas 4 , Nicolas Mendoza 5 , Miguel Quesada-Charneco 1 & Juristo Fonolla 6
1Bone Metabolic Unit (RETICEF), Endocrinology Division, Hospital Universitario San Cecilio, Instituto de Investigación de Granada, Granada, Spain; 2Endocrinology Unit, Hospital General Universitario Rafael Mendez, Lorca, Murcia, Spain; 3Endocrinology, Hospital Comarcal del Noroeste, Caravaca de la Cruz, Murcia, Spain; 4Palacios Institute of Women’s Health, Madrid, Spain; 5Department of Obstetrics and Gynecology, University of Granada, Granada, Spain; 6Nutrition Department, Biosearch S.A, Granada, Spain.
Background: Vitamin D deficiency is highly prevalent and can be associated with adverse health outcomes. Few studies have evaluated the effects of daily consumption of milk fortified with a high dose of vitamin D in a large cohort of healthy postmenopausal women.
Objectives: To determine the effect of daily intake of milk enriched with vitamin D (with or without fructooligosaccharides (FOS)) on vitamin D status, bone mass and cardiovascular risk factors.
Subjects and methods: This was a 2-year randomized controlled study in which 500 healthy postmenopausal women (mean age 58.1±4.8 years) were assigned to receive 500 ml/day of a dairy product to one of three groups: control group (C) with skimmed milk (120 mg/100 ml calcium and vitamin D 0.75 μg/100 ml), group A with skimmed milk enriched with calcium and vitamin D (180 mg/100 ml and 3 μg/100 ml) and group B with skimmed milk enriched with calcium and vitamin D (180 mg/100 ml and 3 μg/100 ml) and FOS (5 g/l). We evaluated serum levels of 25-OH-vitamin D. We also measure anthropometric parameters, biochemical data of glucose metabolism and lipid prolife, and body composition by electrical impedance. Preliminary results in 292 posmenopausal healthy women after 12 months of the nutritional intervention are presented.
Results: After 12 months, changes in vitamin D in the control group (n=105) were non-significant (22.21±7.5 vs 24.16±7.8 ng/ml, P=0.067). In group A (n=108) and group B (n=79) we observed a significant increase in vitamin D (group A 21.5±6.5 vs 27.35±8.8 ng/ml and group B 23.7±10.7 vs 29.0±13.6 ng/ml, P<0.001 for both). In groups A (84%) and group B (72.6%) a high percentage of women reached vitamin D levels >20 ng/ml, compared with the control group (65.5%), P<0.01 for the comparison with control group.
Conclusions: Preliminary data confirms that daily intake of milk highly enriched with vitamin D, with or without FOS, in postmenopausal healthy women induces a significant improvement in vitamin D status.
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