Bone Abstracts

Aim of research: To determine the prevalence of hyperuricemia affecting the Ukrainian men in relation to the bone mineral density and TBS.

Object of research: The Ukrainian men (n=132), age of the examined patients –from 50 to 80 years. Average age of examined patients was 58.2±1.3 years. According to the levels of uric acid in the blood serum, all patients were divided in four quartiles.

Methods of research: Uric acid level in blood plasma was determined by the uricase-peroxidase method, bone mineral density – by means of the ‘Prodigy’ unit (CE Medical systems, model 8743, 2005). The TBS was evaluated using the installed TBS iNsight software for an X-ray densitometer (Med-Imaps, Pessac, France).

Results: The rate of hyperuricemia affecting the Ukrainian men was 23% in the age group of 50–59 years old, 33% – in the age group of 60–69 years old, 29% – in the age group of 70–79 years old. The frequency of osteoporosis in men with hyperuricemia was lower compared with men who had a normal level of uric acid (4 and 17% at the level of the lumbar spine, and 4 and 15% at the level of femoral neck). Bone mineral density was significantly higher in case of men having the highest levels of uric acid in the lumbar spine (F=2.78; P=0.04), radius 33% (F=3.96; P=0.01) and total body (F=2.70; P=0.04). TBS was significantly higher in the patients who had the lowest levels of uric acid compared with the patients who had the highest level of uric acid (Q1=1.17±0.02, Q4=1.04±0.02; P<0.05).

Conclusions: We determined that men with the low levels of uric acid had the significantly lower levels of bone mineral density, but the TBS in men who have the highest levels of uric acid is higher.