Bone Abstracts

Introduction: It has been reported that low bone mass is common in patients with pulmonary disorders such as chronic obstructive pulmonary disease. However, in healthy non-smoking women, the relationship between bone mass and pulmonary function has yet to be clarified. The object of this study was to determine whether pulmonary function is related to BMD in healthy non-smoking women based on menopausal status.

Methods: This study was a cross-sectional study based on data obtained from the Korean National Health and Nutrition Examination Survey (KNHANES), a nation-wide representative survey conducted by the Korean Ministry of Health and Welfare in 2010. This study included 506 subjects who had never smoked and analyzed data concerning pulmonary function and BMD.

Results: Functional vital capacity (FVC) and forced expiratory volume in 1 second (FEV₁) were correlated with BMD at lumbar spine, femur neck (FN), and total hip in premenopausal women (P=0.030, P=0.003, and P=0.019 respectively for FVC; P=0.015, P=0.006, and P=0.059 respectively for FEV₁). However, FVC and FEV₁ were only correlated with BMD at FN in postmenopausal women (P=0.003 for FVC and P=0.006 for FEV₁). BMI, FVC, and FEV₁ were significantly related with BMD at FN, even after adjusting for age and other confounding factors (β=0.334, P<0.001, β=0.145, P=0.017, and β=0.129, P=0.037 respectively) in premenopausal women. However, only age and BMI were correlated with BMD at FN (β=−0.268, P=0.001 and β=0.384, P<0.001) in postmenopausal women after adjusting for confounding factors.

Conclusions: Pulmonary function, including FVC and FEV₁ are associated with BMD at FN in healthy non-smoking premenopausal women but not in postmenopausal women.