ECTS2014 Poster Presentations Osteoporosis: evaluation and imaging (43 abstracts)
1D.F. Chebotarev Institute of gerontology NAMS Ukraine, Kyiv, Ukraine; 2Center of Bone diseases, Lausanne University Hospital, Lausanne, Ukraine.
The aim of this study was to evaluate the trabecular bone score (TBS), bone mineral density (BMD) and body composition in women of various ages.
Materials and methods: 494 women aged 4189 years (mean age, 63.6±0.4 years; mean height, 1.61±0.003 m; and mean weight, 74.0±0.6 kg) were examined. The patients were divided into the following age-dependent groups: 4049 years (n=35), 5059 years (n=130), 6069 years (n=177), 7079 years (n=128), and 8088 years (n=24). BMD of total body, PA lumbar spine and proximal femur were measured by the DXA method (Prodigy, GEHC Lunar, Madison, WI, USA) and PA spine TBS were assessed by the TBS iNsight Software package installed on our DXA machine (Med-Imaps, Pessac, France).
Results: We observed a significant decrease of TBS (L1L4) as a function of age (4049 years, 1.321±0.021; 5059 years, 1.245±0.012; 6069 years, 1.189±0.011; 7079 years, 1.166±0.001; and 8088 years, 1.114±0.033; F=14.28; P<0.001). We also found the lumbar spine BMD (4049 years, 1.156±0.038 g/cm2; 5059 years, 1.068±0.018 g/cm2; 6069 years, 1.022±0.016 g/cm2; 7079 years, 1.003±0.001 g/cm2; and 8089 years, 1.007±0.037 g/cm2; F=5.11; P=0.0005) and proximal femur BMD (4049 years, 1.012±0.037 g/cm2; 5059 years, 0.940±0.013 g/cm2; 6069 years, 0.923±0.011 g/cm2; 7079 years, 0.843±0.012 g/cm2; and 8089 years, 0.741±0.020 g/cm2; F=20.09; P<0.001) decrease with age.
Significant correlation was observed between TBS and BMD of lumbar spine (TBS=0.93+0.26×BMD (L1L4); r=0.37; t=8.61; P<0.001), proximal femur (TBS=0.97+0.27×BMD (L1L4); r=0.29; t=6.61; P<0.001) and lean (TBS=1.34−0.000003×lean mass (g); r=−0.11; t=−2.47; P=0.01) and fat (TBS=1.25−0.000003×fat mass (g); r=−0.100; t=−2.200; P=0.03) masses.
Conclusion: TBS and BMD of the examined women significantly decreased with ageing. We have also found a significant correlation of TBS and BMD of lumbar spine and proximal femur, lean and fat masses.