ECTS2014 Poster Presentations Cell biology: osteoclasts and bone resorption (22 abstracts)
In vitro inhibitory activity on RANKL-mediated osteoclastogenesis of Glossogyne tenuifolia extract
Shih-Wei Wang 1, , Han-Chun Kuo 1, , Hsia-Fen Hsu 3 , Yuan-Kun Tu 4 , Tien-Tsai Cheng 5 & Jer-Yiing Houng 1,
1Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, Taiwan; 2Department of Internal Medicine, Division of Allergy, Immunology, and Rheumatology, E-DA Hospital, Kaohsiung, Taiwan; 3Department of Nutrition, I-Shou University, Kaohsiung, Taiwan; 4Department of Orthopedics, E-Da Hospital, Kaohsiung, Taiwan; 5Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital – Kaohsiung Medical Center, Chang-Gung University College of Medicine, Kaohsiung, Taiwan.
Receptor activator of nuclear factor kappa B ligand (RANKL)-induced activation of NF-κB and MAPKs signaling pathways is critical to osteoclastogenesis. Glossogyne tenuifolia has been used as an antipyretic, detoxication, and anti-inflammatory herb tea in Penghu Island, Taiwan. This study investigated the effects of G. tenuifolia ethanolic extract (GTE) on the formation of RANKL-activating osteoclasts and expression of signaling pathways using a RAW264.7 cells model. GTE significantly inhibited the RANKL-induced formation of TRAP-positive multinucleated osteoclasts in a dose-dependent manner. GTE inhibited RANKL-induced activation of nuclear factor of activated T-cells (NFATc1) and suppressed the phosphorylation of NF-κB/p65 and JNK. Additionally, GTE reduced the phosphorylated forms of osteoclast survival-related signaling molecules, including NF-κB, JNK, p38, and Akt. Taken together, these results reveal that GTE may have potential in the development of health food against osteoclast-related diseases such as osteoporosis.
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