ECTS2014 Poster Presentations Cell biology: osteoclasts and bone resorption (22 abstracts)
Zoledronic acid differently affects long-bone and jaw bone remodeling
Jenny A.F. Vermeer 1 , Greetje A.P. Renders 1 , Marion A. van Duin 1 , Ineke D.C. Jansen 2 , Lieneke F. Bakker 1 , Sophie A. Kroon 1 , Teun J. de Vries 2 & Vincent Everts 1
1Department of Oral Cell Biology and Functional Anatomy, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, MOVE Research Institute Amsterdam, Amsterdam, The Netherlands; 2Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands.
Bisphosphonates (BPs) are used to treat bone diseases characterized by excessive bone resorption. However, BPs can negatively affect the jaw bone by causing osteonecrosis of the jaw. Previously, we showed that BPs differently affect long-bone and jaw osteoclast precursors. Administration of BPs in vivo reduced the number of jaw bone marrow cells, without affecting long-bone marrow cells. Yet, BPs increased bone volume and mineral density of both long bone and jaw. Here, we investigated whether in vivo exposure to BPs has a different effect on long-bone and jaw osteoclasts and the remodeling of these two types of bone. Animal studies were approved by the Animal Welfare Committee. Female C57BL/6J mice were injected i.p. with zoledronic acid (ZA, 0.5 mg/kg weekly) for 1, 3, or 6 months. Its effect on osteoclasts and bone formation was studied. ZA did not affect number of long-bone and jaw osteoclasts in vivo. Interestingly, 6 months of treatment inhibited bone formation in the long bones without affecting the jaw. Finally, we showed that BPs can cause tooth root resorption. In conclusion, our results show that BPs differently affect long-bone and jaw bone marrow cells and bone remodeling in those bones. These findings provide more insight into the mechanism of bone-site-specific effects of bisphosphonates, such as osteonecrosis of the jaw. Also, we showed for the first time, that BPs can stimulate osteoclasts and their activity at the molar roots.
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Bone Abstracts
ISSN 2052-1219 (online)
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