ECTS2014 Poster Presentations Bone biomechanics and quality (22 abstracts)
Structural analysis of tooth and jawbone in a type 2 diabetes mouse model
Silvia Pabisch 1 , Tsuguno Yamaguchi 2 , Yasushi Koike 2 , Kenji Egashira 2 , Shinsuke Kataoka 2 , Wolfgang Wagermaier 1 , Richard Weinkamer 1 , Michiaki Murakoshi 2 & Peter Fratzl 1
1Max Planck Institute of Colloids and Interfaces, Potsdam, Germany; 2LION Corporation, Odawara, Japan.
In type 2 diabetes mellitus (T2DM) patients, an increased fracture risk is observed, although the bone mineral density is even higher than in non-diabetic patients, which raises the question of the quality of the organic and inorganic matrix in bone1,2. T2DM is also known to favor inflammation of the gingiva and paradontosis in general. However, little is known about the mineral nano-architecture in the mandible and about the possible influence of diabetes. Using synchrotron small-angle X-ray scattering (SAXS), we investigated the nanostructure of the mandible and tooth of a model of obese diabetes mice (KKAy) in comparison to controls (C57BL/6). Parameters determined were bone mineral particle size (thickness T and length L) and the alignment (rho-parameter) of the particles in the organic matrix3. The samples were embedded cross-sections of the jaw bone centered around the first molar of 15-week-old animals. Line scans with 30 μm resolutions (beam- and stepsize) were performed from the lingual to the buccal side of the mandible, including root dentin. Significant differences in the nanostructure of the mineral particles between the lingual and buccal side were found. In particular, the mineral platelets are thicker and more aligned on the buccal side compared to the lingual side in the control mice. In the diabetes model, the measurements indicate an even stronger structural difference between both sides of the tooth. We speculate that this high asymmetry in the bone microarchitecture might be due to asymmetric loads during mastication between the buccal and the lingual side of the tooth.
References
1. Hamann C, Kirschner S, Guenther K-P & Hofbauer LC. Nature Reviews. Endocrinology 2012 8 297–305.
2. Vestergaard P, Rejnmark L & Mosekilde L. Calcified Tissue International 2009 84 45–55.
3. Märten A, Fratzl P, Paris O & Zaslansky P. Biomaterials 2005 31 5479–5490.
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Bone Abstracts
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