Bone Abstracts

To assess the associations among diseases causing disability requiring support, including i) musculoskeletal diseases (knee osteoarthritis (KOA), lumbar spondylosis (LS), and osteoporosis (OP)); ii) metabolic risk factors for cardiovascular diseases, including overweight (OW), hypertension (HT), dyslipidaemia (DL), and impaired glucose tolerance (IGT); and iii) mild cognitive impairment (MCI).Among 1690 participants (596 men and 1094 women) at the baseli...

Bone marrow lesions (BMLs), previously denoted bone marrow edema are detected as water signals on MR scans (low intensity on T1 weighted images and high intensity on T2 weighted scans). Previous histologic studies were unable to demonstrate any edematous changes at the tissue level, which led us to hypothesize that the water signal stems from increased vascularization accompanying a high turnover state in bone. To test this hypothesis we performed tetracy...

Objective: To examine bone mineral density (BMD) at the femoral neck (FN) and lumbar spine (LS) in patients (pts) with early axial spondyloarthritis (axSpA).Methods: 73 pts (33 men and 40 women) with early axSpA were included in this study. Pts fulfilled ASAS criteria. Pts enrolled in the study had inflammatory back pain for < 5 years: mean disease duration 19.9±14.4 months. Mean age 28.3±6.4 years, mean BASDAI 4.1±1.9; mean ASDAS-CRP ...

Rheumatoid arthritis (RA) is marked by the persistent inflammation and osteodestruction, causing progressive disability. Osteoclast progenitors (OCPs) represent a subpopulation of peripheral blood monocytes and have been shown to be present in healthy subjects and arthritic patients. The aim of our study was to determine the phenotype, frequency and osteoclastogenic potential of OCPs in the peripheral blood and synovial fluid of RA patients in response to anti-TNF therapy....

Purpose: The purpose of this study is to analyse regional differences in the microstructural and mechanical properties of the distal femur depending on osteoarthritic changes using micro-images based on finite element analysis.Materials and methods: Distal femur specimens were obtained from ten donors composed of ten women with OA (mean age of 65 years, ranging from 53 to 79). As controls, the normal distal femur was sampled from age and gender matched d...

Introduction: Cathepsin K is necessary for bone matrix resorption. Excessive resorption associated with osteoporosis and osteoarthritis can be reduced by cathepsin K inhibition. MIV-711, a highly selective cathepsin K inhibitor, successfully attenuates both bone resorption and cartilage degradation in non-clinical studies.Aim: To determine safety, tolerability, pharmacokinetics and pharmacodynamics of MIV-711 during multiple oral dosing to postmenopausal...

Beside the bone mass, structural changes are important determinants of the bone strength. Patients with osteoarthritis (OA) seem protected against femoral neck (FN) fracture. When compared to osteoporosis, FN in OA are characterized by a higher bone mass and a better trabecular microarchitecture (Blain et al., 2008, Boutroy et al., 2011). The presence of microcracks is one of the determinants of the bone strength. The aim of this study was to evaluate the mic...

Objectives: The purpose of this study is to determine the chemical information in trabecular bone by Raman spectroscopy in the osteoarthritic and non-osteoarthritic distal femur.Materials and methods: Distal femur specimens were obtained from ten donors composed of ten womens with OA (mean age of 63 years, ranging from 50 to 76). As controls, the normal distal femur was sampled from age and gender matched donors consisting of ten womens (mean age of 53 y...

There is discussed an interrelation of BMD, progressing of erosive and destructive changes in hands and feet with development of vertebral deformations in rheumatoid arthritis (RA).The aim: To receive data on bone mineral density (BMD), erosive and destructive changes in hands and feet and vertebral deformations in patients with RA.Materials/methods: In this research, it was included 106 women, with RA, age 23–69 years. In all...

Background: The activity of rheumatoid arthritis (RA) is the one of the significant reasons of the increase of bone resorption and decrease of bone mineral density (BMD). The control of activity of inflammatory process with biologics (including rituximab – anti-CD20 antibodies) can be considered as possibility of decrease in bone resorption and BMD stabilization.Objectives: To access the dynamics of BMD after 24 months of treatment with rituximab in...

Aims: To describe different multinucleated giant cell phenotypes and their associations with synovitis in people with rheumatoid arthritis (RA) or osteoarthritis (OA), and in an experimental model of chronic arthritis.Material and methods: A cross-sectional comparative study was performed on samples of knee synovia from age-matched patients with RA, OA, or non-arthritic post mortem (PM) controls. OA synovia were stratified by histological inflammation gr...

Diseases affecting the musculoskeletal system are a major cost burden to society. Articular cartilage loss or damage in these diseases is detected by radiography and measuring decreases in joint space width (JSW). The early stages of the disease may remain latent and asymptomatic for many years. This forms the rationale for applying molecular marker technology (biomarkers) to identify patients prone to joint diseases. One such biomarker is cartilage oligomeric matrix protein (...

Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are systemic, immune-mediated diseases. RA’s main targets are the peripheral joints while AS has the axial skeleton and enthesis as the principal affected areas. RA is characterized by bone erosions and impaired repair whilst AS is typified by bone overgrowth. The causes for these differences are not yet understood; however we hypothesize that AS patients’ monocytes receive reduced osteoclastogenic stimuli and...

Total hip arthroplasty (THA) is the treatment for severe hip osteoarthritis. It improves the quality of life, pain and patient autonomy. However, a periprosthetic resorption may occur, in 3–5% of patients after 10 years of the primary surgery requiring implant replacement. Bisphosphonates (BP), inhibitors of bone resorption, represent a potential candidate for modulating periprosthetic bone loss. Randomized controlled trials have also suggested that BP could prevent early...

Objective: Cartilage loss and subchondral bone changes are hallmarks of osteoarthritis (OA). The Wnt family is involved in the regulation of bone and cartilage. We have shown that the Wnt/β-catenin pathway is activated in bone during OA, but the effect of its inhibition in bone in cartilage remodeling is unknown. We here investigated the impact of the bone-specific inhibition of Wnt during the development of OA.Methods: Partial meniscectomy (Mnx) wa...