Bone Abstracts

Contents

• Clinical Update
• • Postmenopausal osteoporosis, vitamins and minerals
  • • Calcium and vitamin D: an update on benefits and risks

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    • Selenium

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    • Vitamin K and bone health

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    • Postmenopausal osteoporosis: when to treat and what with?

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    • Treatment of postmenopausal osteoporosis: long-term benefit and risk

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  • Management of parathyroid diseases
  • • Hypoparathyroidism: diagnosis and management

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    • Primary hyperparathyroidism: epidemiology and diagnosis

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    • Treatment of primary hyperparathyroidism

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    • Parathyroid diseases and multiple endocrine neoplasia

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    • Secondary and tertiary hyperparathyroidism

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  • Allied Health Professionals Session
  • • Epidemiology of ageing, fracture and falls. Geographic and ethnic disparities in osteoporotic fractures

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    • Imaging the older patient

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    • Self-perceived fracture risk among post-menopausal women: how to communicate fracture risk (IS3)

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    • Vitamin D and bone health in the older patient

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  • Main Symposium
  • • Periosteocytic osteolysis in preclinical models

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    • Osteocytes and cortical bone quality in human bone diseases

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  • Imaging - from cell to structure
  • • Imaging and fracture risk prediction

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    • Multiphoton microscopy of cell migration

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  • Vascular calcification
  • • Mechanisms of vascular calcification

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    • Clinical aspects

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  • Maintaining muscle during life
  • • Making muscle in the embryo and the adult, role of muscle stem cells

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    • New targets for pharmacological treatment of sarcopenia in old age

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  • Anabolic treatment of osteoporosis
  • • Limitations to anabolic stimulation of bone formation

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    • Clinical use of anabolic drugs

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  • New approaches to fracture prediction
  • • Virtual physiological human

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    • Goals of treatment for osteoporosis

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• Clinical Debate
• • (1)
  • • Debate: there are more benefits than risks associated with HRT in postmenopausal women: for the motion

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    • Debate: there are more benefits than risks associated with HRT in postmenopausal women: against the motion

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• Workshops
• • Extracellular vesicles: from old to new frontiers
  • • Matrix vesicles and mineralisation

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    • Tumour derived vesicles in bone metastasis

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    • Extracellular RNAs and cell to cell communication

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  • Genetics of bone disease
  • • GWAS: what comes next?

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    • Epigenetics

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    • Pharmacogenetics

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  • Blood supply in pathophysiology of bone
  • • Functional role of blood vessels in bone

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    • Vessel-tissue interactions in the skeletal system

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    • Skeletal blood flow in bone repair

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  • Endocrine regulation of bone
  • • Hyponatremia, sodium metabolism and bone

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    • Bone sparing glucocorticoids

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    • Thyroid hormones and bone

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  • The interactive extracellular matrix
  • • The non-collageous matrix network in bone and cartilage

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    • Collagenous matrix and cell behaviour

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    • Skeletal genetic diseases involving matrix proteins

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  • Osteoimmunology
  • • Osteochondral alterations in osteoarthritis

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    • Inflammation, bone destruction and osteoproliferation in spondylarthritis

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    • TRAP mutations and immunology

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• Educational Symposium
• • Educational Symposium 1
  • • Abstract unavailable

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    • Abstract unavailable

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    • Abstract unavailable

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  • Educational Symposium 2
  • • Hypophosphatasia

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    • Gaucher's disease

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    • Updated biology of vitamin D: from the blood vessel to the bone

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• Oral Communications
• • Phosphate metabolism, fracture repair and osteoarthritis
  • • Type 2 cannabinoid receptor protects against osteoarthritis in mice

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    • Study of Hyp or Phex null male fetuses reveals that eightfold increased FGF23 does not alter fetal-placental phosphorus homeostasis or prenatal bone formation and mineralization

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    • Klotho deficiency impairs mineralization by vitamin D hormone-driven upregulation of osteopontin and pyrophosphate in bone

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    • Long-term Fgf23 deficiency induces renal and skeletal PTH resistance in vitamin D receptor-ablated mice

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    • The role of alarmins in fracture repair

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    • The role of neuropeptide Y Y1 receptor signalling in fracture healing

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  • Osteoporosis epidemiology
  • • Low serum thyrotropin level and duration of suppression as a predictor of major osteoporotic fractures - the openthyro register cohort

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    • Effect of daily vitamin B12 and folic acid supplementation on fracture incidence in elderly with an elevated plasma homocysteine level: B-PROOF, a randomized controlled trial

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    • Hip fractures in Sweden and Denmark 1987-2010 - period and cohort effects

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    • Are the high hip fracture rates among Norwegian women explained by impaired bone material properties?

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    • IGFBP1 as a predictor of hip fractures

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    • Absolute fracture and mortality risk in patients with a recent non-vertebral fracture: the contribution of secondary osteoporosis or other metabolic bone disease (SECOB)

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  • Osteoclasts, gastric hormones and HIF
  • • HIF prolyl hydroxylase 2 (PHD2) controls bone homeostasis through HIF2[alpha] - a novel player in osteohematology

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    • Activation of the P2Y2 receptor enhances osteoclast function by stimulating the release of ATP, a pro-resorptive extracellular nucleotide

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    • Thyroid hormones stimulate osteoclastogenesis via TR[alpha]-dependent actions in osteoblasts

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    • RANKL enhances TNF-induced osteoclast formation by degrading TRAF3 in osteoclast precursors independent of TRAF6

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    • Double incretin receptor knock-out (DIRKO) mice present with alterations of trabecular and cortical microarchitectures and bone strength.

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    • Skeletal effects of the gastrin receptor antagonist netazepide in H+/K+ATPase beta-subunit deficient mice

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  • Genetics of bone disease
  • • PLS3 mutations in X-linked osteoporosis with fractures

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    • Variants in the LRP4 gene are associated with bone mineral density in males and females

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    • Exome-chip meta-analysis identifies novel associations of coding variants in BSN and GLRA4 with lumbar spine BMD in 27 339 adults of European descent

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    • Variants in RIN3 predispose to Paget's disease of bone

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    • Bone microarchitecture, geometry and volumetric BMD assessed using HR-pQCT in adult patients with hypophosphatemic rickets

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    • Gout is associated with an excess risk of osteoporotic fracture: findings from a Danish registry

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  • Important pathways in bone biology and cancer
  • • In vivo efficacy of a pharmacological inhibitor of TNAP to prevent arterial calcification and its associated cardiac hypertrophy and mortality

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    • Regulation of bone metastasis by the IKK[beta]/FoxO3a axis

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    • Beta haemoglobin (hbb) is a novel marker of breast cancer progression

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    • WNT5A has anti-prostate cancer effects and protects against bone metastases

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    • Rs55710688 in the Kozak sequence of WNT16 increases translation efficiency and is associated with osteoporosis related parameters

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    • Enhanced load adaptation in long bone of cathepsin K-deficient mice

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  • Osteoporosis treatment and the effects of physical activity
  • • Sex differences in bone acquisition of pre-pubertal children are consequence of differential responsiveness to mechanical loading

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    • Gender-specific associations between physical functioning, bone quality, and fracture risk in older people

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    • Vitamin D is low in obesity, and this is due to greater volume of distribution

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    • Long-term denosumab therapy further reduces the rate of non-vertebral fractures in women with persisting low hip BMD after 3 years

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    • The effect of bisphosphonate treatment on osteoclast precursor cells in postmenopausal women with rsteoporosis: The TRIO study

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    • External auditory canal and middle ear diseases in bisphosphonate-treated osteoporosis patients: A Danish national register based cohort study

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• Hot Topic Oral Communications
• • (1)
  • • Atypical femoral fracture and bisphosphonate use: association with duration, cessation, gender, and type of bisphosphonate: a population-based study of 172 cases.

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    • Osteoblast-specific ablation of p38[alpha] blunts the bone anabolic activity of parathyroid hormone

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    • Consistent, marked and rapid increases in hip and spine BMD with the PTHrP1-34 analog, abaloparatide (BA058), compared to placebo and teriparatide

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    • Sclerostin prevents mice from osteoarthritis despite high subchondral bone accretion

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    • Skin inflammation causes bone loss with reduced bone formation through systemic IL-17A release

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• Clinical Case Oral Communications
• • (1)
  • • Molecular diagnosis of osteopetrotic patients with atypical presentations using traditional approaches and exome sequencing

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    • Hyperphosphatemic familial tumoral calcinosis and hyperphosphatemic hyperostosis syndrome caused by a novel GALNT3 mutation; Long-term clinical outcome and phenotypic variability.

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    • Absence of ER cation channel TMEM38B/TRIC-B causes recessive osteogenesis imperfecta by dysregulation of collagen post-translational modification

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    • Two novel compound heterozygous mutations in LRP5 cause osteoporosis pseudoglioma syndrome

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• Oral Posters
• • Clinical
  • • A transdermal patch delivering the PTHrP1-34 analog, abaloparatide (BA058), dose-dependently increases spine and hip bmd compared to placebo

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    • Abaloparatide (BA058), a novel human PTHrP analog, restores bone mass and strength in the aged osteopenic ovariectomized cynomolgus monkey

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    • PTH treatment induces WNT10b expression in humans lymphoid cells

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    • Denosumab treatment in women with osteoporosis reduces hip cortical porosity

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    • Continuous modelling-based bone formation could explain sustained increases in hip bone mineral density with denosumab treatment

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    • Changes in lumbar spine QCT, DXA and TBS with denosumab, alendronate or placebo in postmenopausal women with low bone mass

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    • In postmenopausal women previously treated with an oral bisphosphonate and at higher risk of fracture, denosumab significantly increases bone mineral density compared with ibandronate and risedronate

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    • Effects of up to 15 years of recombinant human GH replacement therapy on the skeleton in adult GH deficiency: the Leiden Cohort Study

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    • Zoledronate prevents lactation induced loss of bone strength and micro-architecture

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    • Zoledronate reverses bone marrow adiposity in disuse osteopenic rats

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    • A randomized, double-blind, placebo-controlled, ascending, single-dose study of a human monoclonal anti-FGF23 antibody (KRN23) in X-linked hypophosphatemia

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    • Pharmacokinetics and pharmacodynamics of a human monoclonal anti-FGF23 antibody (KRN23) after ascending single-dose administration in patients with X-linked hypophosphatemia

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    • Decrease in expression of MMP3 in osteoblast protects against bone loss

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    • Ten year alendronate use does not adversely affect bone quality compared to 5 years use: a human iliac crest biopsy study

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    • Predictors of second fracture while on treatment with oral bisphosphonates: a multinational retrospective cohort study

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    • The impact of common comorbidities (as measured using the Charlson index) on hip fracture risk in elderly men: a population-based cohort study

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    • Dynamic changes in bone marrow adiposity during the menstrual cycle

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    • Does bone density, bone strength, sarcopenia or dynapenia explain greater risk of fracture in obesity?

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    • Effect of subcutaneous recombinant human parathyroid hormone, rhPTH(1--84), on skeletal dynamics in hypoparathyroidism: findings from the 24-week replace and 8-week relay phase III clinical trials

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    • No beneficial effects of vitamin D supplementation in muscle function or quality of life in primary hyperparathyroidism: results from a randomized controlled trial.

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  • Pre-Clinical
  • • Novel evidence that apolipoprotein A-I deficiency is implicated in the pathogenesis of osteoporosis in mice

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    • Apolipoprotein-E deficiency predisposes to the development of osteoporosis following long-term exposure to western-type diet, in mice

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    • The peroxisome proliferator-activated receptor alfa agonist fenofibrate improves the effect of high-impact exercise on bone and muscle mass in ovariectomized rats

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    • New insights in the bone-muscle axis: the novel myokine irisin is involved in skeletal metabolism

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    • Selective inhibition of BET bromodomains epigenetic signaling interferes with the bone-associated tumor vicious cycle

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    • Disturbed cartilages of the mandible in achondroplasia are associated with defective mandible shape and position

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    • Novel mechanisms of action and new target genes of the glucocorticoid receptor in inflammatory bone disease and bone loss

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    • Bone matrix mineralization after sclerostin antibody treatment in a mouse model of osteogenesis imperfecta

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    • Innovative cell-based strategy for systemic delivery of soluble RANKL in RANKL-deficient osteopetrotic mice

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    • Bone secreted dickkopf-related protein 1 ameliorates osteoarthritis in mice

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    • Increased expression of PTX3 in non-hematopoietic periosteal cells during fracture healing

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    • Enhancement of fracture repair by upregulation of the innate immune response

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    • CXCL8 and CCL20 enhance osteoblast-mediated osteoclastogenesis

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    • Telomerase promotes osteoblast differentiation by modulating IGF-signaling pathway

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    • PRKG1: A novel regulator of human skeletal (mesenchymal) stem cell differentiation

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    • The roles of CDC42 in bone development

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    • Inhibition of bone remodeling by bisphosphonate displaces the plasma cell niche into the spleen

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    • Syndecan-2 is a new negative modulator of Wnt signaling within bone marrow

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    • Inhibition of PDE5 decreases bone mass through inhibiting canonical Wnt signaling

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    • Protein malnutrition attenuates bone anabolic response to PTH in female rats

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• Poster Presentations
• • Arthritis and other joint diseases: translational and clinical
  • • Mutual associations among diseases causing disability, such as musculoskeletal diseases, metabolic syndrome components, and mild cognitive impairment: a 3-year follow-up of the ROAD study

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    • Bone marrow lesions are characterized by increased bone turnover and increased vascularity

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    • Bone loss in patients with early axial spondyloarthritis

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    • Phenotypic and functional characterization of osteoclast progenitors in circulatory and synovial compartments of patients with rheumatoid arthritis

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    • Regional differences in microstructural and mechanical properties of the distal femur in health and osteoarthritis

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    • MIV-711, a highly selective cathepsin K inhibitor: safety, pharmacokinetics and pharmacodynamics of multiple oral doses in healthy postmenopausal women

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    • Do osteophytes protect femoral neck against fracture in osteoarthritis?

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    • Comparison of trabecular bone composition between osteoarthritis and non-osteoarthritis of distal femur by Raman spectroscopy

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    • The characteristics of bone mineral density, erosive and destructive changes in joints of hands and feet, vertebral deformities in patients with rheumatoid arthritis

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    • The influence of the 24-month treatment with anti-CD20 antibodies (rituximab) on bone mineral density in patients with rheumatoid arthritis

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    • Multinucleated giant cells in synovia from people with rheumatoid arthritis or osteoarthritis

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    • Cartilage oligomeric matrix protein assay on the IDS-iSYS automated system

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    • RANK expression is reduced in circulating monocytes from ankylosing spondylitis patients

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    • Effect of risedronate on painful periprosthetic resorption of total hip arthroplasty: preliminary observational study

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    • Bone secreted dickkopf-related protein 1 ameliorates osteoarthritis in mice

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  • Bone biomechanics and quality
  • • Inhibition of RANKL-mediated bone remodeling decreases bone damage and improves strength in response to fatigue loading

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    • Bone fragility and matrix hypermineralization is rescued in homozygous OI Brtl mice mutants

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    • Influence of PTH treatment on the bone tissue mechanics of rats with type 2 diabetes mellitus using mechanical tests and finite element modelling

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    • Scanning acoustic microscopy reveals heterogeneity of mechanical properties due to collagen orientation in mice cortical bone

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    • Subchondral bone sclerosis in the DMM model of murine OA is not associated with changes in either BMD or nanomechanical properties

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    • Are the high hip fracture rates among norwegian women explained by impaired bone material properties?

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    • Bone matrix mineralization is preserved during perimenopausal stage in healthy women

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    • Influence of estrogen receptor and β-catenin signalling activation on mechanically induced bone formation in ovariectomized mice

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    • Beneficial effects of a GIP mimetic on bone material properties

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    • Normal bone matrix mineralization in patients with chronic obstructive pulmonary disease

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    • Structural analysis of tooth and jawbone in a type 2 diabetes mouse model

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    • Long term treatment with odanacatib maintains normal trabecular biomechanical properties in ovariectomized adult monkeys as demonstrated by micro-CT based finite element analysis of the vertebral cores

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    • Dietary creatine influence on bone metabolism in rats

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    • Systemic treatment with strontium ranelate does not influence the healing of femoral mid-shaft defects in rats

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    • Strength training is capable of stimulating transcription factors Runx2 and osterix and ensure better bone quality in wistar rats during aging

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    • Excessive intake of soy milk affects bone development

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    • Dietary arginine influence on bone metabolism in rats

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    • Relationships between morphometric, densitometric and mechanical properties of tarsometatarsal bone in ostriches (Struthio camelus)

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    • The surface and the volume trace element compound of the of biological bone apatite

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    • Strength features of humerus in rats with defects in tibiae after 60-day administration of sodium benzoate

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    • Comparing two types of bovine bone composition, structure and hardness based on their ecological effect and nutrition

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    • Bone matrix mineralization after sclerostin antibody treatment in a mouse model of osteogenesis imperfecta

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  • Bone development/growth and fracture repair
  • • Development and characterization of novel biodegradable scaffold materials

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    • Bone shaft revascularization after marrow ablation is dramatically accelerated in BSP−/− mice, along with faster haematopoietic recolonization

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    • NFI-C regulates osteoblast differentiation via control of osterix expression

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    • Exosomes derived from human platelet lysate affect MSC functions in vitro

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    • Bone age in hemiplegic cerebral palsy: is there a correlation with hand function and limb length?

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    • Subchronic co-administration to cadmium, diazinon and selenium causes apparent symptoms of osteoporosis in adult male rats

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    • Sex-related differences of morphometric and densitometric properties of lumbar vertebrae in silver foxes (Vulpes vulpes)

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    • 1,25-Dihydroxyvitamin D3 modulates the cross-talk between mesenchymal stem cells and macrophages

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    • Midkine deficiency significantly delayed chondrogenesis during fracture healing in mice

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    • Mechanisms of action and osteogenic activity of bone marrow mesenchymal stromal cells are donor dependent

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    • Spatial arrangement of mesenchymal stem cells regulates their immunomodulatory properties on macrophages

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    • Whole-body vibration with extremely low-amplitude accelerates early-stage bone defect healing with reducing angiogenesis

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    • Forearm fracture in premenopausal women, a disorder of trabecular corticalization

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    • Alkaline phosphatase interacts with collagen during mineralization

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    • Cadmium induced embryopathy: nitric oxide rescues teratogenic effects of cadmium

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    • Caspase-7 participates in osteogenic molecular networks

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    • MicroCT analysis of caspase-7 deficient mice revealed impaired osteogenesis

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    • Roles of Bone morphogenetic proteins signalling in the bony repair of injured growth plate cartilage in young rats

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    • The influence of dexamethasone administered prenatally on cartilage in newborns of spiny mouse (Acomys cahirinus)

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    • Anabolic and anti-catabolic effect of Strontium ranelate in an in vivo bone healing model

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    • Single cell analysis of caspase-3 in apoptotic and non-apoptotic cells during mouse limb development

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    • Comparison of a novel bone device OSTEOGROW with commercial bone devices in regard of a local inflammatory reaction

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    • Effects of treatment with different bone-resorption inhibitors on alveolar wound healing process of old acyclic female rats

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    • Fas ligand in formation of hard tissues

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    • Effects of maternal administration of [beta]-hydroxy-[beta]-methylbutyrate on humerus properties in newborn piglets

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    • Adiponectin induce elasticity of bones

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    • Efficacy of a combination of simvastatin and poly(DL-lactic-co-glycolic acid) in stimulating the regeneration of bone defects

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    • Influence of BMI on pubertal development and bone mass accrual in apparently healthy school children aged 6-17 years

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    • Interrelationships between body weight, bone-specific alkaline phosphatase BAP, IGF1 and morphometric, densitometric and mechanical properties of deciduous mandibular teeth properties in Polish Merino Sheep

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    • Prevalence of vertebral fractures, after 50 years old

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    • Increased expression of PTX3 in non-hematopoietic periosteal cells during fracture healing

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    • Enhancement of fracture repair by upregulation of the innate immune response

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    • The roles of CDC42 in bone development

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    • Effect of recombinant human parathyroid hormone, rhPTH(1--84), on bone turnover markers and bone mineral density in patients with hypoparathyroidism: 24-week, open-label REPEAT study

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    • Candidate reference methods for the harmonisation of parathyroid hormone (PTH) assays: consideration of variant forms including phosphorylated PTH

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    • S.C. injection of recombinant human parathyroid hormone rhPTH(1--84) in thigh provides a more prolonged pharmacokinetic profile and a greater calcemic response when compared with injection in abdomen

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    • Bone turnover and FGF-23 levels in vitamin D-deficient critically ill patients with and without acute kidney injury

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    • Low calcium-phosphate diet attenuates dietary protein deficiency-mediated impairment of bone growth by blunting the decrease in serum IGF1 and in hepatic GH receptor gene expression

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    • Relationship between vitamin D levels and carotid arterial stiffness in postmenopausal women with hypertension

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    • Elevated blood serotonin decreases bone volume via a mechanism involving insulin and calcitriol

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    • Effects of TSH and calcitriol on bone metabolism: in vivo and in vitro study

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    • Associations among vitamin D binding protein polymorphisms and concentrations and total, free, and bioavailable serum 25-hydroxyvitamin D concentrations in finnish adults

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    • Histological and analytical studies in the role of melatonin in the formation and composition of incremental lines in dentin

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    • 1,25-Dihydroxy vitamin D assay with on-board sample purification on the IDS-iSYS automated system

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    • Comparison of proportions of T lymphocyte subsets according to serum 25(OH) vitamin D levels in postmenopausal women

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    • Serum serotonin: useful for the assessment of the bone metabolism status?

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    • Relation between 25-hydroxyvitamin D level and blood pressure in healthy young Saudi women: effect of adiposity

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    • The impact on calcium metabolism when replacing intact PTH with teriparatide treatment in patients with hypoparathyroidism

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    • Circulating myostatin in type 2 diabetes subjects: relationship with bone metabolism and fractures

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    • Serum concentration of bone tissue metabolism markers in 28 and 180-day-old Polish Large White pigs

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    • Ectopic parathyroid glands: imaging methods and strategy of surgical treatment

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    • Zoledronate prevents lactation induced loss of bone strength and micro-architecture

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    • A randomized, double-blind, placebo-controlled, ascending, single-dose study of a human monoclonal anti-FGF23 antibody (KRN23) in X-linked hypophosphatemia

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    • Pharmacokinetics and pharmacodynamics of a human monoclonal anti-FGF23 antibody (KRN23) after ascending single-dose administration in patients with X-linked hypophosphatemia

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    • Effect of subcutaneous recombinant human parathyroid hormone, rhPTH(1--84), on skeletal dynamics in hypoparathyroidism: findings from the 24-week replace and 8-week relay phase III clinical trials

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  • Cancer and bone: basic, translational and clinical
  • • Inhibition of TGF-β signaling pathway blocks the development of osteosarcoma lung metastases

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    • Preclinical efficacy of PF-04942847, a novel HSP90 inhibitor, in osteosarcoma

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    • Interleukin 34 promotes angiogenesis and increases blood cells adherence to endothelial cells

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    • Osteoblast-secreted extracellular vesicles stimulate the expansion of CD34⁺ human umbilical cord blood cells

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    • TRAF2, but not TRAF6, regulates breast cancer induced osteoclastogenesis and osteolysis.

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    • Biological markers of aggressive giant cell tumour of bone: an immunohistochemical study

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    • Changes in bone mineral density and biochemical markers of bone turnover in postmenopausal women with breast cancer initiating aromatase inhibitors therapy

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    • Bone quality of metaplastic woven bone of mixed metastases: a FTIRI analysis

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    • The effect of granulocyte colony-stimulating factor in adults undergoing autologous peripheral blood stem cell collection

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    • Paget's sarcoma -- A case report in Korea

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    • Selective inhibition of BET bromodomains epigenetic signaling interferes with the bone-associated tumor vicious cycle

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  • Cell biology: osteoblasts and bone formation
  • • Overexpression of Sp7 in osteoblasts inhibits osteoblast maturation but enhances angiogenesis in bone

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    • Reduced bone formation and increased adiposity with insulin resistance in interleukin-11 deficient mice

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    • Downregulation of Smurf1 is involved in odontoblast differentiation induced by histone deacetylase inhibitors

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    • Osteoblast-specific overexpression of amphiregulin leads to transient increase in cancellous bone mass in mice

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    • Collagen XIII in bone homeostasis

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    • Advanced glycation end products inhibit the mineralization of marrow stromal cells by binding the receptor for AGEs and increasing TGF-[beta] expression and secretion

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    • Age-dependent loss of microvesicular galectin-3 and its consequences on bone formation in vitro and in vivo

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    • Osteopontin as a novel substrate for proprotein convertase 5/6 (PCSK5) in bone

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    • Levels of circulating vesicular microRNA-31 increase with age as well as in the case of osteoporosis and inhibit osteogenic differentiation capacity of mesenchymal stem cells

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    • Bone-anabolic effects of sulforaphane, a naturally occurring isothiocyanate on bone metabolism

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    • N-linked glycosylation as a critical mechanism of PTH-resistance in osteoblasts in high glucose conditions

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    • Epigenetic modifications and canonical WNT signaling enable direct programming of non-osteogenic cells into osteoblasts

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    • Inhibitory effect of GH on the adipogenic commitment of mesenchymal stromal cells derived from human trabecular bone

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    • EGF inhibits Wnt/[beta]-catenin-induced osteoblast differentiation in a Smurf1-dependent manner

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    • HBO increased osteogenic differentiation of MSCs via regulating Wnt processing, secretion, and signaling

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    • Effect of osteoporosis in the transcriptional profile of osteoblastic cells from bone marrow and calvaria of ovariectomized rats

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    • Treatment with allopurinol and oxypurinol promotes osteoblast differentiation and increases bone formation

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    • Is the bone marrow envelope a reservoir of osteoblast progenitors?

      ba0003pp121
    • Extracellular protein Edil3 stimulates matrix calcification via [alpha]5[beta]1 and ERK pathway in MC3T3E1 cells

      ba0003pp122
    • miR-468 controls Runx2 expression during early differentiation of Runx2 in mice

      ba0003pp123
    • MiR-320a and miR-483-5p are over-expressed in osteoblasts from osteoporotic fractured hips

      ba0003pp124
    • The significance of Bcl-2-associated athanogene-1 (BAG-1)-mediated protein interactions in osteoblast development

      ba0003pp125
    • Glucose-dependent insulinotropic polypeptide directly affects collagen deposition and maturation in osteoblast cultures

      ba0003pp126
    • Regulation of adipo- and osteo-genesis of multipotent cells by strontium through stimulation of small Rho GTPases: A 3D bioreactor study

      ba0003pp127
    • Vitamin K2 (MK-7) is involved in bone and energy homeostasis: Effects on osteoblast, adipocyte and [beta]-cell regulatory loops

      ba0003pp128
    • Modulation of sclerostin expression by estrogen via BMP-2 signaling in human mesenchymal stromal cells and osteoblasts

      ba0003pp129
    • Decrease of mineralization by FGF1 is linked to up-regulation of ANKH and OP in osteogenic differentiation and conversion

      ba0003pp130
    • Hyperbaric oxygen promotes osteogenic differentiation of mesenchymal stem cells by regulating sclerostin expression and Wnt/[beta]-catenin signaling

      ba0003pp131
    • Roles of phospholipase D during physiological and vascular calcification

      ba0003pp132
    • Chemical composition of apatites formed by matrix vesicles during bone mineralization

      ba0003pp133
    • Osteogenic markers are decreased in SHR rats during in vitro osteoblast differentiation

      ba0003pp134
    • High-resolution molecular validation of self-renewal and spontaneous differentiation in adipose-tissue derived human mesenchymal stem cells cultured in human platelet lysate

      ba0003pp135
    • Transcriptional profile of osteoblastic cells cultured on titanium surfaces modified by oxidative nanopatterning

      ba0003pp136
    • IGF1 stimulates protein synthesis by enhancing mRNA translation rate in osteoblasts

      ba0003pp137
    • Metabolism and synthesis activity of calvaria osteoblasts from offspring of rats treated with caffeine during pregnancy

      ba0003pp138
    • Effect of lactation on the osteogenic potential of bone marrow mesenchymal stem cells of rats

      ba0003pp139
    • Release kinetic of prolyl hydroxylase inhibitors from collagen barrier membranes in vitro

      ba0003pp140
    • An infrared assay of the kinetics of phosphate-release from physiological substrates in living cells

      ba0003pp141
    • Cell attachment and proliferation of bone marrow-derived osteoblast on zirconia of various surface treatment

      ba0003pp142
    • Utilization of L-mimosine in pulp regeneration: lessons from cell culture and tooth slice organ cultures

      ba0003pp143
    • Pro-osteogenic properties of nacre extract on two cell lines, primary human osteoblasts and MC3T3-E1 cell line

      ba0003pp144
    • Effects of strontium ranelate on the bone-like mineralized matrix produced in osteoblast cell cultures

      ba0003pp145
    • Strontium ranelate increases osteoblast cell proliferation and differentiation and the formation of bone-like mineralized matrix on different titanium substrates

      ba0003pp146
    • Differential gene expression of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are modulated during osteogenic/odontogenic differentiation from human dental pulp stem cells (DPSCs) by BMP-7

      ba0003pp147
    • Expression of BDNF gene in the femur of aged vs adult rats

      ba0003pp148
    • Telomerase promotes osteoblast differentiation by modulating IGF-signaling pathway

      ba0003pp149
    • PRKG1: A novel regulator of human skeletal (mesenchymal) stem cell differentiation

      ba0003pp150
    • Syndecan-2 is a new negative modulator of Wnt signaling within bone marrow

      ba0003pp151
  • Cell biology: osteoclasts and bone resorption
  • • Involvement of LIGHT in multiple myeloma bone disease

      ba0003pp152
    • Zoledronic acid differently affects long-bone and jaw bone remodeling

      ba0003pp153
    • Disruption of PLEKHM1 and TRAFD1 (FLN29) interaction impairs osteoclast resorptive activity

      ba0003pp154
    • Role of caveolin-1 in osteoclastogenesis

      ba0003pp155
    • Interleukin-34 and macrophage-colony stimulating factor interact to form a heteromeric and functional cytokine

      ba0003pp156
    • CCN2 induces osteoclastogenesis by regulating RANK/RANKL/OPG system

      ba0003pp157
    • Study of the molecular effects of disease-causing mutations in RANK using human protein expression models

      ba0003pp158
    • Arachidonic acid and docosahexaenoic acid inhibits osteoclastogenesis and bone resorption in human CD14+ monocytes, in vitro

      ba0003pp159
    • EEIG1 interacts with RANK receptor and positively regulates osteoclastogenesis

      ba0003pp160
    • Ultrastructural imaging of the osteoclast secretory machinery in 3 dimensions

      ba0003pp161
    • The role of IL-6 as a modulator of osteoclastic resorption in vitro in acute Charcot osteoarthropathy

      ba0003pp162
    • The molecular mechanism of n-butanol extracts of Panax notoginseng on RANKL-induced osteoclastogenesis in RAW264.7 cells

      ba0003pp163
    • Novel highly sensitive ELISA to measure free, bioactive, human soluble RANKL

      ba0003pp164
    • Foreign body giant cells do not have the capacity to resorb bone

      ba0003pp165
    • Functional read out of perturbed osteoclast behaviour in an in vitro model of Gaucher's disease

      ba0003pp166
    • Inhibitory effect of Crossostephium chinense extract on RANKL-activating osteoclastogenesis in patients with tophaceous gout

      ba0003pp167
    • Effect of C-reactive protein on TRAP-positive multinucleated cell formation in RANKL-induced RAW264.7 cell culture

      ba0003pp168
    • Mechanosensitive TRP channels are required for Ca2+ signaling in osteoclastogenesis

      ba0003pp169
    • DBZ, a [gamma]-secretase inhibitor, suppresses bone resorption by inhibiting c-Src activity

      ba0003pp170
    • The purinergenic receptor P2Y14 is essential for RANKL-induced osteoclastogenesis

      ba0003pp171
    • In vitro inhibitory activity on RANKL-mediated osteoclastogenesis of Glossogyne tenuifolia extract

      ba0003pp172
    • Inhibition of bone remodeling by bisphosphonate displaces the plasma cell niche into the spleen

      ba0003pp173
  • Cell biology: osteocytes
  • • Structural analysis of tooth and jawbone in a type 2 diabetes mouse model

      ba0003pp174
    • Low estrogens, weak bones: unravelling estradiol remodelling effect in bone metabolic/lipid profiles

      ba0003pp175
    • Effects of osteocyte apoptosis and mechanical strain on osteoblast proliferation and migration

      ba0003pp176
  • Chondrocytes and cartilage
  • • The transcription factor Foxc1 controls endochondral ossification through the direct regulation of PTHrP and Cola10a1 expression under the partnership with Gli2 and Runx2

      ba0003pp177
    • LDL receptor-related protein 5 governs Wnt-mediated osteoarthritic cartilage destruction

      ba0003pp178
    • Osteoclasts inhibit the Wnt canonical pathway in chondrocytes

      ba0003pp179
    • Selective targeting of bone and cartilage with multivalent dendritic polyanions

      ba0003pp180
    • Hyperbaric oxygen treatment suppresses Wnt/[beta]-catenin signaling and matrix metalloproteinases in degenerated human intervertebral disc cells

      ba0003pp181
    • Hyperbaric oxygen therapy reduces the catabolic pathway mediated by toll-like receptors in human osteoarthritic chondrocytes

      ba0003pp182
    • Meniscus - Cartilage paracrine crosstalk in osteoarthritis

      ba0003pp183
    • Therapeutic education of patients treated for osteoarthritis: medical advice and assessment of patients knowledge level

      ba0003pp184
    • Disturbed cartilages of the mandible in achondroplasia are associated with defective mandible shape and position

      ba0003pp185
  • Genetics
  • • Pharmacogenomics of bisphosphonate treatment in Paget's disease of bone: retrospective and prospective analysis

      ba0003pp186
    • A novel mutation in IFITM5, encoding BRIL, impairs osteoblast production of PEDF and causes atypical type VI osteogenesis imperfecta

      ba0003pp187
    • Correlation of miRNA-mRNA regulatory network profile with bone mass in inbred strains of mice

      ba0003pp188
    • A polymorphism in the TGF-[beta]1 gene affects TGF-[beta]1 secretion

      ba0003pp189
    • Premature aging of bone is delayed by dietary restriction

      ba0003pp190
    • Functional analysis of a promoter polymorphism of optineurin, a gene associated to Paget's disease of bone

      ba0003pp191
    • Genetic determinants of bone mineral density loss in aromatase inhibitors treatment in the B-ABLE Cohort

      ba0003pp192
    • MK-7 enhances expression of genes related to bone, enamel and dentin, and reduces the expression of genes related to apoptosis in developing murine molars

      ba0003pp193
    • Analysis of genetic polymorphisms in relation to bone mineral density and fracture risk in maltese postmenopausal women

      ba0003pp194
    • Interactions between the effects of polymorphisms in the RANK and RANKL genes affects bone mass

      ba0003pp195
    • Association of methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) with clinical indicators of osteoporosis in postmenopausal Slovak women

      ba0003pp196
  • Muscle, physical activity and bone
  • • Girls with Turner syndrome have normal muscle force but decreased muscle power

      ba0003pp197
    • Efficacy of two exercise programs in patients with early rheumatoid arthritis: 6-month randomized controlled trial

      ba0003pp198
    • Anthropometric characteristics of postmenopausal women depending on appendicular skeletal mass

      ba0003pp199
    • Body composition and bone mineral density in postmenopausal women

      ba0003pp200
    • Prevalence of ‘dysmobility syndrome' in community dwelling older adults: findings from the Hertfordshire Cohort Study

      ba0003pp201
    • Vertical trabeculae are thinned more rapidly than horizontal trabeculae in skeletal unloaded rats

      ba0003pp202
    • Sarcopenic obesity worsens bone strength: hip strength analysis in post-menopausal women

      ba0003pp203
    • Sarcopenia in patients scheduled to undergo orthopaedic surgery

      ba0003pp204
    • Volumetric bone mineral density at the distal radius in premenopausal Spanish women and grip strength: role of calcium intake

      ba0003pp205
    • Influence of sarcopenic obesity on osteoporosis and vertebral fragility fractures in post-menopausal women

      ba0003pp206
    • Epidemiology of hip fractures in over 50 years old in merida venezuela 2008--2011

      ba0003pp207
    • A new functional test for the evaluation of the erector muscles of the spine: the Back Extensor Test (BET)

      ba0003pp208
    • Does bone density, bone strength, sarcopenia or dynapenia explain greater risk of fracture in obesity?

      ba0003pp209
    • No beneficial effects of vitamin D supplementation in muscle function or quality of life in primary hyperparathyroidism: results from a randomized controlled trial

      ba0003pp210
    • The peroxisome proliferator-activated receptor α agonist fenofibrate improves the effect of high-impact exercise on bone and muscle mass in ovariectomized rats

      ba0003pp211
    • New insights in the bone-muscle axis: the novel myokine irisin is involved in skeletal metabolism

      ba0003pp212
  • Osteoporosis: evaluation and imaging
  • • HIV patients have deteriorated bone material properties assessed by in vivo microindentation

      ba0003pp213
    • Bone marrow densitometry by clinical high resolution computed tomography of human vertebrae

      ba0003pp214
    • Bone quality in diabetes mellitus type 2

      ba0003pp215
    • Correlation between osteoporosis and dental caries in Korean population

      ba0003pp216
    • An observational study investigating the prevalence of anaemia in hip fracture patients

      ba0003pp217
    • Sacral insufficiency fracture associated with osteoporotic spinal compression fracture: analysis of incidence and clinical factors

      ba0003pp218
    • Experimental glucocorticoid-induced bone loss in mice is strongly influenced by the strain

      ba0003pp219
    • The fracture outpatient clinic: what is the additional value of vertebral assessments and which individuals should be more actively recruited?

      ba0003pp220
    • Comparison of diagnostic strategies to detect prevalent vertebral fracture for adults over age 50: use of vertebral fracture assessment or spine radiography

      ba0003pp221
    • Association of CT-based finite element estimates of femur strength with fracture status in three clinical studies on post-menopausal women

      ba0003pp222
    • Bone mineral density and bone turnover markers in patients with thyroid cancer and L-T₄ suppressive therapy after 25 years of follow-up

      ba0003pp223
    • Discordance between bone mineral density and speed of sound measures of bone: the Canadian Multicentre Osteoporosis study

      ba0003pp224
    • Utilizing bisphosphonate binding kinetics and soft tissue-derived input functions to differentiate changes in long bone and vertebra bone metabolism using in vivo fluorescent molecular tomography

      ba0003pp225
    • Combining BINDEX and FRAX in treatment decision pathway for osteoporosis

      ba0003pp226
    • New point of care method for osteoporosis diagnostics in us

      ba0003pp227
    • Changes of health-related quality of life 36 months after vertebral and distal forearm fracture: results from Icuros in Lithuania

      ba0003pp228
    • Assessment of the possible use of the Austrian model of frax algorithm to predict fragility fracture risk factors in Ukrainian women

      ba0003pp229
    • Combination of spine TBS and clinical risk factors (CRF) can be used to detect women with osteoporotic fracture: a US study

      ba0003pp230
    • The impact of physical activity on estimated bone stiffness as assessed by multisite quantitative ultrasound: the Canadian Multicentre Osteoporosis study

      ba0003pp231
    • Serum creatinine profiles in hip fracture patients, an observational study

      ba0003pp232
    • aBMD at the hip measured by DXA overestimate cortical vBMD assesed by QCT scans

      ba0003pp233
    • Influence of age factor on the structural and functional organization of dentoalveolar system bone tissue in rats

      ba0003pp234
    • The impact of vitamin D and calcium intake on estimated bone stiffness as assessed by multisite quantitative ultrasound: the Canadian Multicentre Osteoporosis study

      ba0003pp235
    • Improved assessment of vertebral cortex thickness by means of analytical deconvolution of radial bone mineral density distributions

      ba0003pp236
    • Reference intervals for bone turnover markers in Spanish premenopausal women

      ba0003pp237
    • Correlation between localized femoral BMD T-scores and fractures site of hip, and evaluation of the sensitive of FRAX probability in hip fracture patients

      ba0003pp238
    • Impact of metal artefacts in QCT of the hip caused by a contralateral Gamma type nail: an ex vivo study

      ba0003pp239
    • Glucocorticoids aggravate reduction in mineral and lean mass in active juvenile idiopathic arthritis

      ba0003pp240
    • Peripheral densitometry in the assessment of fracture risk in adults with cerebral palsy

      ba0003pp241
    • A systematic review of diagnostic accuracy of VFA using DXA in people aged over 50

      ba0003pp242
    • Trabecular bone score, bone mineral density and body composistion in men of different ages

      ba0003pp243
    • Trabecular bone score, bone mineral density and body composistion in women of different ages

      ba0003pp244
    • Prevalence of co-morbid conditions among fracture neck of femur patients in an acute hip unit

      ba0003pp245
    • Do osteophytes protect femoral neck against fracture in osteoarthritis?

      ba0003pp246
    • Evaluation of bone mineral density at the inhabitants of Karelia

      ba0003pp247
    • Effect of minodronate on vertebral bone microarchitecture in vivo assessed by computed tomography

      ba0003pp248
    • Prevalence of post-operative medical and surgical complications among fracture neck of femur patients in an acute hip unit

      ba0003pp249
    • Vitamin D levels in male patients with systemic lupus erythematosus

      ba0003pp250
    • The ability of quantitative ultrasound variables to identify osteoporosis in various regions of interest in female corticosteroid users

      ba0003pp251
    • The development of a mathematical model to predict the time to osteoporosis using DEXA scanning

      ba0003pp252
    • Bone mass in HIV male patients undergoing antiretroviral therapy

      ba0003pp253
    • Ten-year absolute fragility fracture risk and central DXA assessment: does hypovitaminosis D matter in menopausal women?

      ba0003pp254
    • Dynamic changes in bone marrow adiposity during the menstrual cycle

      ba0003pp255
  • Osteoporosis: pathophysiology and epidemiology
  • • Sarcopenia increased mortality among elderly men

      ba0003pp256
    • Molecular evidence of osteoblast dysfunction in elderly men with osteoporotic hip fractures

      ba0003pp257
    • Socio-economic status and hip fracture risk: a region-wide ecological study

      ba0003pp258
    • High sclerostin levels in primary biliray cirrhosis: relationship with cholestasis and bone remodelling

      ba0003pp259
    • Dietary phosphorus intake is positively associated with some radial and tibial pQCT bone traits in premenopausal females with seemingly high calcium intake

      ba0003pp260
    • The relationship between pulmonary function and bone mineral density in healthy non-smoking women: The Korean National Health and Nutrition Examination Survey (KNHANES) 2010

      ba0003pp261
    • Bone mineral density and hip geometry in men and women with type 2 diabetes: Korea National Health and Nutrition Examination Survey 2008

      ba0003pp262
    • Interval changes in bone mineral density in exercising young women with apparent athlete triad syndrome

      ba0003pp263
    • Calcium and vitamin D nutritional status effect on oral health evaluated in a group of young college women

      ba0003pp264
    • High prevalence of vertebral fractures at time of screening for orthotopic liver transplantation

      ba0003pp265
    • Adipose tissue expression of adipocytes and osteoporosis in COPD

      ba0003pp266
    • Fracture risk and the osteoporosis treatment care gap in patients with type 1 diabetes

      ba0003pp267
    • BMD and biochemical bone markers in premenopausal amenorrhea

      ba0003pp268
    • Comparison of peripheral volumetric bone mineral density, quantitative ultrasound and standard radiological methods for monitoring bone mineral density changes 2 years postpartum

      ba0003pp269
    • FRAX underestimates fracture risk in Korean postmenopausal patients with diabetes: The Korea National Health and Nutrition Examination Survey 2008-2009

      ba0003pp270
    • Secondary causes for osteoporosis significantly contribute to fracture risk in patients with osteopenia and a recent fracture

      ba0003pp271
    • Serum 25-hydroxyvitamin D levels of healthy adult women in Greece

      ba0003pp272
    • Adipokines and grelin, nutritive status and bone metabolism in chronic obstructive pulmonary disease

      ba0003pp273
    • Hyperuricemia, bone mineral density and TBS of Ukrainian men

      ba0003pp274
    • Influence of vitamin D deficiency to structural and functional state of bone tissue in schoolchildren

      ba0003pp275
    • Is it necessary to consider fracture site in osteoporosis?

      ba0003pp276
    • Quantitative ultrasonometry of the phalanges in post-menopausal women with type 2 diabetes mellitus: the first results of a 3-year longitudinal study

      ba0003pp277
    • Fluoride exposure accelerates the development of postmenopausal osteoporosis: animal model

      ba0003pp278
    • Influence of vitamin D deficiency on bone turnover markers in men of different age

      ba0003pp279
    • Bone health in patients with type 2 diabetes mellitus

      ba0003pp280
    • State of vitamin D sufficiency Ukrainian schoolchildren

      ba0003pp281
    • Vitamin D levels in Lebanese population: do we need to alter the base line for insufficiency?

      ba0003pp282
    • Prevalence of osteopenia using calcaneal quantitaive ultrasound among adults in Dubai

      ba0003pp283
    • Low referral rate of lebanese males for vitamin D testing

      ba0003pp284
    • Osteoporosis risk assessment in a welsh district general hospital

      ba0003pp285
    • Striking osteoporosis following prolonged immobilization; a case report

      ba0003pp286
    • Vitamin D status in sunny Lebanon

      ba0003pp287
    • Decrease in expression of MMP3 in osteoblast protects against bone loss

      ba0003pp288
    • The impact of common comorbidities (as measured using the Charlson index) on hip fracture risk in elderly men: a population-based cohort study

      ba0003pp289
    • Novel evidence that apolipoprotein A-I deficiency is implicated in the pathogenesis of osteoporosis in mice

      ba0003pp290
    • Apolipoprotein-E deficiency predisposes to the development of osteoporosis following long-term exposure to western-type diet, in mice

      ba0003pp291
    • CXCL8 and CCL20 enhance osteoblast-mediated osteoclastogenesis

      ba0003pp292
    • Inhibition of PDE5 decreases bone mass through inhibiting canonical Wnt signaling

      ba0003pp293
  • Osteoporosis: treatment
  • • Targeting the sealing zone, a novel strategy to prevent bone degradation while maintaining bone formation: in vivo proof of concept in three models of pathological bone loss

      ba0003pp294
    • Bisphosphonate treatment of postmenopausal osteoporosis and circulating levels of DKK1 and sclerostin: effects of treatment regimens

      ba0003pp295
    • Correlation between 25-OH vitamin D, γδTCR lymphocytes and acute phase reaction after the first zoledronic acid infusion for post-menopausal osteoporosis

      ba0003pp296
    • Contribution of circulating sclerostin and estradiol for inadequate response to bisphosphonate therapy in women with postmenopausal osteoporosis

      ba0003pp297
    • Investigating effects of novel conjugate drugs for the treatment of osteoporosis

      ba0003pp298
    • Association between allopurinol use and hip fracture in older patients discharged from rehabilitation

      ba0003pp299
    • Resveratrol supplementation increases vBMD at the spine in obese men: a randomized controlled trial

      ba0003pp300
    • Effect of gastrointestinal events on treatment patterns, discontinuation, resource utilization, and cost in osteoporosis: an analysis using danish health registries

      ba0003pp301
    • Comparison of osteosarcoma incidence between abaloparatide (BA058) and PTH (1--34) in long term rat studies

      ba0003pp302
    • Gastrointestinal issues and osteoporosis treatment: the medication use patterns, treatment satisfaction, and inadequate control of osteoporosis study (MUSIC-OS)

      ba0003pp303
    • Activin decoy receptor (IIA) ameliorates immobilisation induced loss of bone and muscle mass in mice

      ba0003pp304
    • Treatment with PTH 1--84 influences glucose metabolism trough undercarboxylated osteocalcin

      ba0003pp305
    • The effect of bisphosphonate treatment on sclerostin levels in postmenopausal osteoporosis: the TRIO study

      ba0003pp306
    • Effect of daily intake of milk enriched with a high dose of vitamin D in healthy postmenopausal women: preliminary results from a randomized, controlled and double-blind nutritional trial (The EFICALCIO study)

      ba0003pp307
    • Association of gastrointestinal events and osteoporosis treatment initiation in newly diagnosed osteoporotic Israeli women

      ba0003pp308
    • Treatment of severe vertebral osteoporosis with teriparatide or 1--84-PTH: results from a Danish Database Initiative

      ba0003pp309
    • Risk factors for the development of chronic back pain after percutaneous vertebroplasty vs conventional treatment

      ba0003pp310
    • Rates and reasons for lack of persistence with anti-osteoporotic drugs: analysis of the Campania Region Database

      ba0003pp311
    • Farnesylpyrophosphate synthase rs2297480 polymorphism and the response to the zoledronic acid in the treatment of postmenopausal osteoporosis

      ba0003pp312
    • Preclinical evaluation of the link module from human TSG--6 as a novel anti-resorptive agent for postmenopausal osteoporosis

      ba0003pp313
    • The effect of risedronate on hypogonadal osteoporotic HIV males treated with highly active anti-retroviral therapy: a pilot study

      ba0003pp314
    • Combination therapy with ibandronate and eldecalcitol enhances bone strength without severe suppression of bone formation in aged ovariectomized rats

      ba0003pp315
    • Odanacatib treatment improves lumbar vertebral bone mineral density and strength in orchiectomized rabbits

      ba0003pp316
    • Eldecalcitol improves endothelial function in the femoral artery and prevents bone loss in ovariectomized rats

      ba0003pp317
    • Preferences of patients and health care professionals for osteoporosis drug treatment: a discrete choice experiment

      ba0003pp318
    • Perceived vs objective knowledge in patients with osteoporosis

      ba0003pp319
    • Effects of preventive long-term treatment with strontium ranelate and zoledronic acid to ovariectomized rats on bone microstructure

      ba0003pp320
    • On-treatment safety and efficacy and short-term efficacy of 1--34 parathyroid hormone treatment in severe osteoporosis

      ba0003pp321
    • Non attendance at a Bone Health Clinic following hip fracture

      ba0003pp322
    • To decline screening for osteoporosis: a study on individual decision making, meaning and reasons for non-participation

      ba0003pp323
    • The effects of risk factors on raloxifene, alendronate, and vitamin D treatment in postmenopausal osteoporosis

      ba0003pp324
    • Effect of implant to radiologic result in treating osteoporotic intertrochanteric fracture

      ba0003pp325
    • Undertreatment of osteoporosis: the Medication Use Patterns, Treatment Satisfaction, and Inadequate Control of Osteoporosis Study (MUSIC-OS)

      ba0003pp326
    • Baseline data of the DEVIDE-study: DEnosumab vs Intravenous Ibandronate: a 2-year retrospective head to head real life study

      ba0003pp327
    • Effects of a preventive long duration treatment of ovariectomized rats with strontium ranelate and zoledronic acid on bone mineral density and bone remodeling

      ba0003pp328
    • Analysis of adequacy in prescribing calcium supplements based on the daily dairy intake in patients at risk of osteoporosis

      ba0003pp329
    • Determinants of bone turnover marker response to three oral bisphosphonate therapies in postmenopausal osteoporosis: the TRIO study

      ba0003pp330
    • Prevalence of osteoporosis treatment depending on the risk evaluation of the osteoporotic fractures in patients with rheumatoid arthritis in Russia

      ba0003pp331
    • Denosumab therapy of osteoporosis in patients after solid organ transplantation and impaired renal function

      ba0003pp332
    • Patients with atypical femoral fractures: characteristics, anabolic treatment and long term follow-up

      ba0003pp333
    • Comparison of efficacy teriparatide between denosumab and on hip BMD in women with severe post-menopausal osteoporosis

      ba0003pp334
    • A survey of oral health attitudes and practices amongst bisphosphonate users in UK

      ba0003pp335
    • The effect of alendronate oral jelly in the treatment of osteoporosis in clinical settings

      ba0003pp336
    • Monitoring of calcium intake and vitamin D saturation in Slovak postmenopausal women

      ba0003pp337
    • Patients at high risk of fragility fracture and teriparatide: report from a third level osteoporosis clinic

      ba0003pp338
    • Recommendations for osteoporosis management and fracture prevention for the frail elderly in long-term care

      ba0003pp339
    • A clinical case of pregnancy, delivery and lactation in a patient treated with ibandronic acid 3.0 intravenously

      ba0003pp340
    • Changes on bone turnover markers and bone mineral density in women with postmenopausical osteoporosis treated with denosumab

      ba0003pp341
    • Assessment treatment with denosumab in clinical practice

      ba0003pp342
    • Clinical experience with Denosumab in the treatment of osteoporosis

      ba0003pp343
    • Appropriateness of osteoporosis treatment within a medical in-patient population in a welsh district general hospital

      ba0003pp344
    • Standardized diagnostic and therapeutic pathway for management of patients with skeletal fragility fractures in the Orthopedic and Physiatrist Unit in an Italian hospital: impact on patient outcome

      ba0003pp345
    • Efficacy of Denosumab on bone metabolism after a 12-month treatment, in women with severe post-menopausal osteoporosis

      ba0003pp346
    • The efficacy of the treatment with intravenous ibandronate in common population.

      ba0003pp347
    • Physical performance and risk of fall in elderly people with severe osteoporosis

      ba0003pp348
    • Bisphosphonate-associated atypical femoral fracture, effect of teriparatide

      ba0003pp349
    • Bilateral transient osteoporosis of hip: a case report

      ba0003pp350
    • A transdermal patch delivering the PTHrP1-34 analog, abaloparatide (BA058), dose-dependently increases spine and hip bmd compared to placebo

      ba0003pp351
    • Abaloparatide (BA058), a novel human PTHrP analog, restores bone mass and strength in the aged osteopenic ovariectomized cynomolgus monkey

      ba0003pp352
    • PTH treatment induces WNT10b expression in humans lymphoid cells

      ba0003pp353
    • Denosumab treatment in women with osteoporosis reduces hip cortical porosity

      ba0003pp354
    • Continuous modelling-based bone formation could explain sustained increases in hip bone mineral density with denosumab treatment

      ba0003pp355
    • Changes in lumbar spine QCT, DXA and TBS with denosumab, alendronate or placebo in postmenopausal women with low bone mass

      ba0003pp356
    • In postmenopausal women previously treated with an oral bisphosphonate and at higher risk of fracture, denosumab significantly increases bone mineral density compared with ibandronate and risedronate

      ba0003pp357
    • Zoledronate reverses bone marrow adiposity in disuse osteopenic rats

      ba0003pp358
    • Ten year alendronate use does not adversely affect bone quality compared to 5 years use: a human iliac crest biopsy study

      ba0003pp359
    • Predictors of second fracture while on treatment with oral bisphosphonates: a multinational retrospective cohort study

      ba0003pp360
    • Protein malnutrition attenuates bone anabolic response to PTH in female rats

      ba0003pp361
  • Other diseases of bone and mineral metabolism
  • • Osteogenesis imperfecta in adults: a cross sectional trial

      ba0003pp362
    • Sustained efficacy and tolerability in infants and young children with life-threatening hypophosphatasia treated with asfotase alfa

      ba0003pp363
    • Hypophosphatasia: a retrospective natural history study of the severe perinatal and infantile forms

      ba0003pp364
    • Alkaline phosphatase bone isoform B1x: a marker of impaired osteoblastic function in patients with renal osteodystrophy

      ba0003pp365
    • Gene expression in vascular calcification: are there differences between atherosclerotic changes and media sclerosis?

      ba0003pp366
    • Blockade of Wnt inhibitor Dickkopf-1 improves bone mass and microstructure of osteogensis imperfecta

      ba0003pp367
    • Vitamin D supplementation decreases the occurrence of acute phase response following i.v. bisphosphonate treatment in Paget's disease of bone

      ba0003pp368
    • A homozygous 20 bp intronic deletion in front of exon 8 of the ALPL-gene causes infantile hypophosphatasia: a functional characterization

      ba0003pp369
    • Isoform-specific effects of Sequestosome-1 UBA domain mutations on NF-κB signalling

      ba0003pp370
    • Effect of complete spinal cord injury on bone turnover and bone mineral density evolution: a 1 year follow-up study

      ba0003pp371
    • Comparative effect of Denosumab vs Teriparatide on bone and energy metabolism

      ba0003pp372
    • Involvement of Gla rich protein with pathological calcification during osteoarthritis. Insights into its γ-carboxylation status

      ba0003pp373
    • Clinical presentation of Paget's disease: evaluation of a contemporary cohort and systematic review

      ba0003pp374
    • Osteoprotegerin and bone-like vascular calcification are predictive markers of vulnerable carotid plaques

      ba0003pp375
    • Blocking β-adrenergic signaling attenuates calorie alteration- induced bone marrow adiposity

      ba0003pp376
    • Fine-needle aspiration with PTH measurement facilitates minimally invasive parathyroidectomy - report of two cases

      ba0003pp377
    • Zoledronic acid induces apoptosis on osteoblast and inhibits RANKL-induced osteoclast differentiation

      ba0003pp378
    • Effect of mesenchymal stem cells and platelet-derived growth factor transplantation on the localized radiation-induced ulcerative lesion in rats

      ba0003pp379
    • TNSALP influences neurogenic differentiation by altering gene expression in SH-SY5Y cells

      ba0003pp380
    • The influence of black and white tea on bone development of rat exposured to cadmium and lead

      ba0003pp381
    • Osteogenic differentiation of fibroblast derived from patients with fybrodisplasia ossificans progressiva

      ba0003pp382
    • MicroRNAs as new biomarkers for monitoring of vascular calcification in CKD patients

      ba0003pp383
    • Wnt16 as a new regulator of vascular calcification

      ba0003pp384
    • The effect of vitamin D treatment on pain, fatigue and muscular strength in women with vitamin D deficiency

      ba0003pp385
    • Bone mineral density and micro-architectural changes in advanced chronic kidney disease

      ba0003pp386
    • Heterotopic ossification in 453 chronic spinal injury patients

      ba0003pp387
    • Late onset presentation of osteogenesis imperfecta with additional mutation on GNAS gene: case report

      ba0003pp388
    • Changing clinical profile of primary hyperparathyroidism in Indian patients

      ba0003pp389
    • Bone marrow densitometry by clinical high resolution computed tomography of human vertebrae

      ba0003pp390
    • Excess dietary calcium intake associated with higher Framingham risk score in 25-hydroxyvitamin D deficient male; analysis of the Korea National Health and Nutrition Examination Survey (KNHANES 2008-2011)

      ba0003pp391
    • Serum concentration of bone tissue metabolism markers in 28 and 180-day-old Polish Large White pigs

      ba0003pp392
    • Adult Niemann-Pick disease type B with myositis ossificans: a case report

      ba0003pp393
    • The influence of organic and inorganic Zn supplementation on bone development

      ba0003pp394
    • Assessment of vitamin K status by fully automated IDS-iSYS inaKtiv MGP

      ba0003pp395
    • Melorheostosis: succesfull conservative treatment of polyostotic skeleton affection

      ba0003pp396
    • Serum 25-hydroxyvitamin D may have an association with lower coronary artery calcification score and higher bone mineral density against osteocalcin

      ba0003pp397
    • A study on the effect factors on BMD of affected femur neck in patients with hemiplegia

      ba0003pp398
    • Effect of vitamin D treatment on bone mineral density in deficient immigrant women

      ba0003pp399
    • Pseudoseptical myositis as the prodrome of myositis ossificans

      ba0003pp400
    • Relationship between history of pregnancies and bone mineral density

      ba0003pp401
    • Clinical case of a patient with severe tertiary hyperparathyroidism, osteitis fibrosa cystica and osteomalacia as a consequence of severe vitamin D deficiency

      ba0003pp402
    • Adsorption salivary proteins on dental materias

      ba0003pp403
    • Effects of up to 15 years of recombinant human GH replacement therapy on the skeleton in adult GH deficiency: the Leiden Cohort Study

      ba0003pp404
    • Innovative cell-based strategy for systemic delivery of soluble RANKL in RANKL-deficient osteopetrotic mice

      ba0003pp405
  • Paediatric bone disease
  • • Early intervention with anti-resorptives is essential in OI: a longterm murine study

      ba0003pp406
    • Glucocorticoid-treated boys with Duchenne muscular dystrophy DMD and osteoporosis have higher bone matrix mineralization before and after i.v. bisphosphonate therapy

      ba0003pp407
    • Effect of GOS/FOS on calcium and phosphorus absorption and retention during recovering from undernutrition: experimental model in normal growing rats

      ba0003pp408
    • Ibandronate in the treatment of pediatric osteoporosis

      ba0003pp409
    • Bone health in children with hemolytic anemia: does the pathogenesis of hemolysis determine the phenotype of bone alteration?

      ba0003pp410
    • Tricho-rhino-phalangeal syndrome TRPS: the new three cases from Poland

      ba0003pp411
    • Team management of young persons with osteogenesis imperfecta

      ba0003pp412
  • Steroid hormones and receptors
  • • Chondroitin sulfate chains are co-receptors for interleukin- 34

      ba0003pp413
    • Glucocorticoids suppress inflammation in arthritis via the glucocorticoid receptor in non-hematopoietic cells

      ba0003pp414
    • Vitamin D deficiency and prevention; what is the position of European Calcified Tissue Society?

      ba0003pp415
    • Novel mechanisms of action and new target genes of the glucocorticoid receptor in inflammatory bone disease and bone loss

      ba0003pp416
• Late Breaking Abstracts
• • (1)
  • • Endochrondral ossification, mesenchymal stem cell and Wnt pathway specific loci predict differential skeletal effects in high bone mass

      ba0003lb1
    • Bisphosphonates for osteoporosis and risk of breast cancer: misleading results from observational studies

      ba0003lb2
    • Meta-analysis of randomised trials shows limited evidence to support the use of bisphosphonates for fracture prevention in osteogenesis imperfecta

      ba0003lb3
    • History of cardiovascular events and risk factors for cardiovascular events among osteoporotic patients initiating strontium ranelate in the UK

      ba0003lb4
    • Early exposure to extra vitamin D from food fortification and bone fractures in adolescents: results from the D-tect study

      ba0003lb5