Bone Abstracts

Objectives: The aim of the study was to examine experimentally the possibility smoothing of adverse effects of «fracture syndrome» in the parameters of the growth of the molar row of the mandible with implant in the proximal tibial shaft biogenic hydroxyapatite, saturated with iron at concentrations of 0.05, 0.15 and 0.50%.

Methods: For the experiment were collected 168 white mature male rats were divided into four groups: 1st group, animals that in the proximal tibial shaft was applied the defect, 2nd, 3rd, 4th groups, the animals that formed in the bone defect was implanted biogenic hydroxyapatite, saturated with iron at concentrations of 0.05, 0.15 and 0.50% respectively. Observation periods were 7, 15, 30, 60, 90 and 180 days. After the time of observation rats were euthanized under ether mask anesthesia, extract of mandibles and using calipers measure the length and height of the molar row of the mandible. The results obtained were processed in the program «STATISTICA 5.5».

Results: The height of the molar row in the group of animals with implanted biogenic hydroxyapatite, saturated with iron in a concentration of 0.05% was more parameters comparison group to 90 days at 5.03%, with 0.15% – length of the molar row increased from 30 to 90 per day for 4.85, 2.74 and 3.00%, and the height to only 90 days 3.91%, with 0.50% – length of the molar row increased to 60 days at 2.31%, and the height – decreased to 180 days at 7.88% (P<0.05).

Conclusion: Thus, we can assume that the implantation of biogenic hydroxyapatite, saturated with iron in a concentration of 0.15% is preferable to smooth the negative manifestations of the ‘fracture syndrome’ in relation to the growth parameters of the molar row of the mandible than 0.05 and 0.50%.