ICCBH2013 Poster Presentations (1) (201 abstracts)
Association of volumetric bone mineral density, bone morphometry and trabecular bone micro-architecture with leptin and soluble leptin receptor in adolescent idiopathic scoliosis
Elisa M S Tam 1, , Fiona W P Yu 1, , Vivian W Y Hung 1 , Zhen Liu 2, , Tsz-Ping Lam 1, , King Lok Liu 1, , Bobby K W Ng 1, , Simon K M Lee 3, , Yong Qiu 2, & Jack C Y Cheng 1,
1Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong; 2Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China; 3Lee Hysan Clinical Research Laboratories, The Chinese University of Hong Kong, Hong Kong; 4Joint Scoliosis Research Center, Chinese University of Hong Kong and Nanjing University, Hong Kong.
Objectives: Low bone mass in adolescent idiopathic scoliosis (AIS) has been well reported, however the etiologies of the disease and this abnormal phenotype were still unknown. Leptin have profound effects on bone metabolism and skeletal growth, and was speculated to play a role in the etiopathogenesis of AIS. The objective of this study was to investigate the bone quality in AIS and its association with leptin and soluble leptin receptor (sOB-R).
Methods: This was a case–control study involving 94 newly radiologically diagnosed AIS girls (Cobb angle 12–48°) aged 12–14 years old and 87 age and gender-matched normal controls. Serum total leptin and sOB-R were assayed with ELISA. Non-dominant distal radius was scanned with high resolution peripheral quantitative computed tomography for assessing bone quality in terms of bone morphometry, volumetric bone mineral density (vBMD) and trabecular bone micro-architecture.
Results: AIS girls had higher sOB-R (P=0.006), lower cortical vBMD (P=0.023), higher cortical bone perimeter (P=0.024), and higher trabecular area (P=0.026). Correlation analysis (Table 1) on leptin level indicated that while its correlations with cortical bone parameters were present in both AIS and controls, the correlations with trabecular bone parameters were only present significantly in AIS. For sOB-R, significant correlations were detected with cortical bone parameters only in controls.
| Leptin | sOB-R | |||
| Controls | AIS | Controls | AIS | |
| Cortical vBMD | 0.287† | 0.362† | −0.229* | NS |
| Cortical area | 0.294† | 0.367† | −0.248* | NS |
| Cortical thickness | 0.249* | 0.385* | −0.239* | NS |
| Cortical bone perimeter | 0.261* | NS | NS | NS |
| Trabecular vBMD | NS | 0.303† | NS | NS |
| Meta trabecular vBMD | NS | 0.288† | NS | NS |
| Inner trabecular vBMD | NS | 0.296† | NS | NS |
| Trabecular area | NS | −0.269† | NS | NS |
| Trabecular BV/TV | NS | 0.303† | NS | NS |
| Trabecular thickness | NS | 0.254* | NS | NS |
| *P<0.05 and †P<0.01. NS, not significant. | ||||
Conclusion: This study showed that bone quality in AIS was deranged as compared with normal controls. In addition, the difference in correlation pattern between leptin, sOB-R and bone parameters indicated possible abnormalities in bone metabolism and disturbance on leptin signaling. The implication and how this is linked to the generalized low bone mass and the etiopathogenesis of AIS warrant further studies.
Article tools
My recent searches
My recently viewed abstracts
Authors
Bone Abstracts
ISSN 2052-1219 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more