ICCBH2013 Poster Presentations (1) (201 abstracts)
Association between parameters of bone mass measured by dual energy X-ray absorptiometry and quantitative ultrasound of proximal phalanges in children and adolescents with congenital adrenal hyperplasia
Ezequiel M Gonçalves 1 , Vinicius J O Barbeta 1 , Fábio Bertapelli 1 , Tathyane Krahenbuhl 1 , Luiz Carlos B Ramalho 1 , Juan Eduardo Samur-San Martin 1 , Sofia H V Lemos-Marini 1, & Gil Guerra-Júnior 1,
1Growth and Body Composition Laboratory, Department of Pediatrics, Center for Investigation in Pediatrics (CIPED), University of Campinas (UNICAMP), São Paulo, Brazil; 2Pediatric Endocrinology Unit, Department of Pediatrics, Faculty of Medical Sciences (FCM), University of Campinas (UNICAMP), São Paulo, Brazil.
The chronic use of glucocorticoids in patients with congenital adrenal hyperplasia (CAH) may result in decreased bone mass. Therefore, using simple and accurate methods for assessing bone status in these patients could facilitate the treatment of disease. The purpose of this study was to verify the association between parameters of bone mass measured by dual energy X-ray absorptiometry (DXA) and quantitative ultrasound (QUS) of proximal phalanges in children adolescents with congenital adrenal hyperplasia. We evaluated 26 patients (15 girls and 11 boys) with CAH due 21-hydroxylase deficiency, aged 6–14 years. Bone mineral content (BMC) and bone mineral density (BMD) were assessed with a DXA whole-body scan, model Discovery Wi (Hologic, Bedford, MA, USA). The ultrasound bone parameters, amplitude dependent speed sound (AD-SoS) and bone transmission time (BTT) were assessed for QUS of proximal phalanges using DBM Sonic BP (IGEA, Carpi, Italy) device. No significantly associations were observed between hydrocortisone dose (HC) and bone parameters assessed by DXA and QUS. BTT demonstrated higher correlations with BMC and BMD than AD-SoS (Table 1).
| Correlations | ||||||
| Mean | S.D. | BMD | BTT | AD-SoS | HC | |
| BMC (g) | 1153.96 | 305.83 | 0.94* | 0.78* | 0.46† | 0.13 |
| BMD (g/cm2) | 0.858 | 0.094 | – | 0.65* | 0.53* | 0.07 |
| BTT (μseg) | 0.97 | 0.17 | – | 0.33 | 0.32 | |
| AD-SoS (m/s) | 1897.12 | 84.97 | – | 0.13 | ||
| HC (mg/m2 per day) | 13.42 | 2.61 | – | |||
| *P<0.01 and †P<0.05. | ||||||
In our sample with children and adolescents with CAH due 21-hydroxylase deficiency the bone parameters assessed by DXA and QUS of proximal phalanges demonstrated significantly association. More studies are needed to evaluate the usefulness of QUS method in these patients, given that the QUS is a radiation-free method can be advantageous in monitoring of children and adolescents with CAH.
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ISSN 2052-1219 (online)
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