ECTS2013 Poster Presentations Bone development/growth and fracture repair (40 abstracts)
Intermittent administration of parathyroid hormone (1–34) may induce the formation of cementum and bone: a histological study in rats
Daniel Vasconcelos 1 , Marcelo Marques 2 , Silvana Barros 3 , Any Carolina Vasconcelos 1 , Bruno Benatti 4 & Pedro Novaes 2
1Federal University of Piauí, Parnaíba, Piauí, Brazil; 2University of Campinas, Piracicaba, São Paulo, Brazil; 3University of North Carolina, Chapel Hill, North Carolina, USA; 4Federal University of Maranhão, São Luiz, Maranhão, Brazil.
The aim of this study was to evaluate the effect of anabolic PTH on periodontal repair and mandibular bone defect in rats. Fenestration defects were created unilaterally of lower first molars in Wistar rats (n=32), and both periodontal ligament and cementum were removed. Animals were treated 3 times a week and then assigned to four groups (n=8): i) C14 – placebo administration for 14 days; ii) P14 – PTH administration for 14 days; iii) C21 – placebo administration for 21 days; and iv) P21 – PTH administration for 21 days. Analized: I-extension of the initial defect; II-extension of the remaining defect; III-area of the remaining defect; IV-density of neoformed bone; V-total callus area and staining for tartrate-resistant acidic phosphatase (TRAP); VI-area of the neoformed cementum; VII-polarized light microscopic analysis of root periodontal ligament reattachment. The intermittent PTH administration decreased (P<0.05) both extension and area of the remaining defect, and increased (P<0.05) the neoformed bone density, total callus area, neoformed cementum, reattachment of the periodontal ligament and TRAP-positive cells. Data analysis suggests that the intermittent PTH administration might contribute to bone and periodontal repair in rats.
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