ECTS2013 Poster Presentations Other diseases of bone and mineral metabolism (48 abstracts)
Correlates of tissue mineral density of bone samples from total hip arthroplasty patients with type 2 diabetes: an ex vivo study
Janet Pritchard 1 , Alexandra Papaioannou 1 , Mark Hurtig 2 , Lora Giangregorio 3 , Stephanie Atkinson 1 , Karen Beattie 1 , J.D. Adachi 1 , Justin DeBeer 1 , Mitchell Winemaker 1 , Victoria Avram 1 & Henry Schwarcz 1
1McMaster University, Hamilton, ON, Canada; 2University of Guelph, Guelph, ON, Canada; 3University of Waterloo, Waterloo, ON, Canada.
Introduction: Fracture risk is greater for adults with type 2 diabetes (T2D), despite normal or higher areal bone mineral density (aBMD) compared to controls. Tissue mineral density (TMD), measured by microCT, is more representative of actual mineral density than in vivo aBMD. The aim of this study was to determine whether TMD is greater in adults with T2D, and to investigate the correlates of TMD in adults with T2D.
Methods: Using proximal femur bone sections from elective hip replacement patients, we assessed TMD and bone mineralization density distribution (BMDD) in adults >65 years with (n=14) and without T2D (n=20). A microCT system (GE, London, Canada) was used to obtain images (voxel size =21 μm3) of 5 mm thick bone sections. MicroView ABA 2.1.2 (GE, London, Canada) was used to determine TMD (mg HA/cm3). BMDD analysis was performed using scanning electron microscope (Vega, TESCAN USA), which yielded CaMEAN, CaPEAK, CaWIDTH. Between-group differences were determined using a Student’s t-test. Bivariate linear regression was used to determine correlates (determined a priori) of TMD. A P-value of 0.05 was considered significant.
Results: TMD was not significantly different between adults with T2D (324.18±94.24 mg HA/cm3) compared to those without T2D (309.22±41.26 mg HA/cm3, P=0.541). Table 1 shows the correlates of TMD in adults with T2D.
| Standardized β-coefficient | P-value | |
| T2D diagnosis ≧ 15 years | 0.614* | 0.034 |
| Participant taking biguanide | 0.470 | 0.090 |
| CaMEAN | 0.427 | 0.191 |
| CaWIDTH | −0.859* | 0.001 |
Conclusions: TMD was not different between groups. Lower mineralization heterogeneity and greater number of years with T2D were associated with TMD in adults with T2D. These findings provide exploratory evidence that disease duration and mineralization heterogeneity may be linked to low bone turnover in adults with T2D, which could explain greater fracture risk.
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ISSN 2052-1219 (online)
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