ECTS2013 Poster Presentations Osteoporosis: pathophysiology and epidemiology (49 abstracts)
1Departament of Internal Medicine, Hospital Universitario Marqués de valdecilla IFIMAV, Universidad de Cantabria, RETICEF, Santander, Spain; 2Centro de Salud de Camargo, Camargo, Spain.
Objective: To determine serum 25-lydroxivitamin D (25OHD) and intact parathyroid hormone (PTH) levels in an immobilized population from Northern Spain.
Subjects and methods: We studied 125 immobilized people (37 men and 88 women) aged 53101 years. (85±8 years.). Seventy-five percent of the subjects lived at home, residing in nursing homes the remaining 25%. None of them received antiresorptive therapy, corticosteroids or vitamin D supplements. Serum 25OHD and PTH levels were measured by the Elecsys 2010 automated analyzer (Roche).
Results: Mean (S.D.) serum 25OHD level was 10.4±7.7 ng/ml, and median (range) concentration was 7.6 (4.413.9) ng/ml. 25OHD levels were similar in both sexes (women: 10.4±8.2 ng/ml; men: 10.6±6.6 ng/ml). Ninety-seven percent of subjects had 25OHD levels below 30 ng/ml, while 86 and 62% had values below 20 and 10 ng/ml, respectively. People who lived at home had a 25OHD concentration greater than nursing home residents (11.4±8.0 vs 7.5±6.3 ng/ml, P<0.006). Mean (S.D.) PTH level was 80.5±45.3 pg/ml (median (range), 70.3 (49.392.7) pg/ml). We did not find any difference between both sexes or between people living at home and nursing home residents. Fifty-six percent of the subjects had values over 65 pg/ml (the upper limit of normality).
Conclusions: Vitamin D insufficiency and deficiency are very common among Spanish immobilized adults. Mean PTH levels lie around 80 pg/ml, a value that is above the upper limit of normality for this hormone.
Supported by a grant from ISCIII. Spain (PI11/01092).