ECTS2013 Poster Presentations Cancer and bone: basic, translational and clinical (31 abstracts)
Carcinoid tumors and DXA assessment: a study in 222 menopausal women
Catalina Poiana 1, , Mara Carsote 1, , Rodica Petris 1 , Raluca Trifanescu 1, , Gabriela Voicu 2 & Diana Paun 1,
1Davila UMPh, Bucharest, Romania; 2Parhon Institute, Bucharest, Romania.
Introduction: The bone mineral density loss may be related to cancer. A specific correlation in the neuroendocrine tumors (NET) is not fully described yet.
Aim: The analyze DXA in patients with or without NET.
Material and method: We perfomed central DXA (spine and hip) with a GE Lunar device in post-menopausal women. None of them were previously treated with anti-osteoporotics drugs. The study groups included women with carcinoid tumors (pathological confirmation of the diagnosis) and clinical symptoms of the carcinoid syndrome. This is a transversal study.
Results: Twenty-two patients with confirmed carcinoid tumors were included. The control group consisted in 200 carcinoid free women. The two groups were age-matched: mean age was 57 vs 56.77 years. The two groups were BMI – matched: mean BMI was 23.61 vs 24.01 kg/m2. The mean BMD was: 1.006 vs 1 g/cm2. No statistically significant difference was registered between lumbar BMD (P=0.9). In carcinoid group the WHO categories (normal DXA /osteopenia /osteoporosis) were: 34% / 46% / 20%, while in control group: 25% / 52.5% / 22.5%.
Discussion: The interpretation of this data is limited to the small number of women with carcinoid tumors.
Conclusions: Based on our observations, the DXA-BMD was not statistically significant different in women with carcinoid tumors to non-carcinoid tumors patients. Probably the skeletal assessment is these women is a multi-factorial equation, including not only age, BMI, BMD but different other parameters as 25-OH vitamin D levels, etc.
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