ECTS2013 Poster Presentations Calciotropic and phosphotropic hormones and mineral metabolism (33 abstracts)
The serum serotonin and 25-OH vitamin D levels: a study in 97 menopausal women
Mara Carsote 1, , Mihaela Popescu 2 , Ramona Samoila 2 , Rene Baloescu 2 , Madalina Muler 2 , Adriana Gruia 3 & Catalina Poiana 1,
1Davila UMPh, Bucharest, Romania; 2Parhon Institute, Bucharest, Romania; 3Medlife Center, Bucharest, Romania.
Introduction: The vitamins as B6, C, or D are involved in serotonin metabolism but mostly in central neurotransmitter pathways. There are very few clear data related to 25-OH vitamin D status and serum serotonin (SS) levels.
Aim: We analyze the SS and 25-OH D.
Materials and methods: We included women in menopause. The serum serotonin (SS; normal 100–400 ng/ml) and 25-OH vitamin D (normal 30–100 ng/ml) were performed in fasting status. The statistical analyse was performed with Student’s t-test.
Results: 97 Women (w) were included with mean age of 57.03 years. Based on 25-OH D levels four groups were formed: 1–3 with vitamin D deficiency and group 4 (control) with normal D levels. Group 1 had 31 w with 25-OH D between 1–9.9 ng/ml (mean 6.52 ng/ml), and mean SS of 180.97 ng/ml; group 2 with 40 w having 25-OH D between 10–10.9 ng/ml (mean 14.42 ng/ml), and a mean SS of 153.78 ng/ml, group 3 with mean 25-OH D of 23.47 ng/ml (between 20–29.9) and mean SS of 171.53 ng/ml, including 19 w; group 4 with 7 w, a mean 25-OH D of 37.28 ng/ml (between 30–39.9) and mean SS of 109 ng/ml. Statistically significant differences were obtained between each group of D deficiency (groups 1, 2, or 3) and control group (P=0.02, P=0.1, and P=0.03 respectively); and between all the women with D deficiency (mean SS 166.89 ng/ml) and control group (P=0.04). No statistical significant difference was found between different D deficiency groups.
Discussion: The SS might not be very adequate to analyze its complex metabolism since different levels are found in brain and periphery.
Conclusions: Based on our observations higher levels of serotonin is found in different levels of vitamin D deficiency.
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