ECTS2013 Poster Presentations Calciotropic and phosphotropic hormones and mineral metabolism (33 abstracts)
Vitamin D supplementation during lactation: effect on maternal and offspring's vitamin D status and bone mass–double-blind randomized control trial
Justyna Czech-Kowalska 1 , Maciej Jaworski 1 , Julita Latka-Grot 1 , Dorota Bulsiewicz 1 , Pawel Pludowski 1 , Bogdan Chazan 2 , Beata Pawlus 2 , Grazyna Wygledowska 3 , Anna Zochowska 4 , Maria K Kornacka 5 , Edyta Kryskiewicz 1 , Elzbieta Karczmarewicz 1 & Anna Dobrzanska 1
1The Children’s Memorial Health Institute, Warsaw, Poland; 2Holly Family Hospital, Warsaw, Poland; 3Miedzyleski Hospital, Warsaw, Poland; 4Public Hospital, Otwock, Poland; 5Warsaw Medical University, Warsaw, Poland.
Introduction: Optimal vitamin D intake for lactating women remains controversial. We hypothesized that 1200 IU/day (vs 400 IU/day) of vitamin D during breastfeeding will enhance maternal vitamin D status and bone mass.
Methods: Healthy mothers after term, singleton delivery were randomized to receive vitamin D3: 1200 IU/day (800+400 IU/day from multivitamins) or 400 IU/day (placebo+400 IU/day from multivitamins) during lactation. Serum 25-hydroxyvitamin D (S-25-OHD), PTH, and densitometry were performed in mothers and infants after delivery (V0) and 3 months later (V1). Calcemia and calciuria (urinary calcium:creatinine ratio) were assessed at V1.
Results: 174 mother–infant pairs were recruited. Intention to treat analysis was performed for 137 pairs completed the study (1200 IU/day group (n=70), 400 IU/day group (n=67)). Baseline maternal and neonatal (cord blood) S-25-OHD, PTH and anthropometric measurements were similar among groups. Maternal S-25-OHD increased from 13.65 to 25.7 ng/ml (P<0.0001) and from 16.1 to 24.5 ng/ml (P<0.0001). Maternal S-25-OHD (V1) was significantly higher in 1200 than 400 IU/day group (25.7 vs 24.5 ng/ml; P=0.049) but comparable among infants (33.9 vs 32.9 ng/ml; P=0.165). While percentage of maternal S-25-OHD >30 ng/ml was similar in both groups (22.85 vs 22.39%) at V1. Maternal PTH decrease from 28.6 to 22.1 pg/ml (P<0.0001) and from 30.4 to 23.3 pg/ml (P<0.0001) in the 1200 and 400 IU/day groups respectively. There were no differences between groups in maternal and neonatal PTH, bone mass, serum, and urinary calcium at V1.
Conclusions: Vitamin D intake at a dose 1200 IU/day is not effective in achieving maternal S-25-OHD >30 ng/ml and reducing bone mass loss during lactation. Breastfeed infants receiving 400 IU/day of vitamin D have adequate S-25-OHD irrespective of maternal supplementation up to 1200 IU/day.
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ISSN 2052-1219 (online)
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