ECTS2013 Poster Presentations Calciotropic and phosphotropic hormones and mineral metabolism (33 abstracts)
A mixture of GOS/FOS ® added to a low calcium (ca) diet improved ca, phosphorus (p) and magnesium (mg) absorption: experimental model in normal growing rats
Gabriel Bryk 1, , Macarena Gonzales Chaves 1, , Clarisa Marotte 1, , Daniela Medina 2 , Magali Zeni Coronel 2 , Maria Luz de Portela 3 & Susana Noemi Zeni 1
1Cátedra De Bioquímica General y Bucal. Fac. De Odontología, Uba, Buenos Aires, Argentina; 2Laboratorio de Enfermedades Metabólicas Óseas, Hospital de Clínicas, Instituto de Inmunología, Genética y Metabolismo (Inigem) Conicet- Uba, Buenos Aires, Argentina; 3Cátedra de Nutrición. Facultad de Farmacia y Bioquímica Uba, Buenos Aires, Argentina.
A mixture of Galacto-oligosaccharides (GOS) and Fructooligosaccharides (FOS) are added to commercial infant formula to promote an intestinal microbiota similar to that prevalent in breast-fed infants to improve Ca bioavailability and general health, but their mechanisms are under debate.
Our objective was to evaluate the beneficial effects of the mixture of GOS/FOS added to infant formulae, on the absorption of Ca, Mg and P of a low Ca diet. Changes in intestinal pH, absorption percentage (Abs) and in bone mineral density (BMD) were determined in an experimental model of normal growing rats.
Male Wistar rats (n=10/group) were fed one of the three experimental diets from weaning to 40 days of age. All diets were prepared according to AIN’93-G rodent diet except for Ca content. A.5 and A.3 contained 0.5 and 0.3% of Ca, respectively; GF.3 contained 0.3%Ca and 5.3% of GOS/FOS.
Dietary consumption and body weight (BW) were evaluated three times per week and weekly, respectively. Ca, Mg and P absorption percentage was determined at the beginning and during the last 3 days of the study. At the end of the experience (t=f), caecal pH, total skeleton (tsk) and tibia BMDs were evaluated by DXA (Lunar corp.)
Results: at=f (mean±SD)
| Caecal Ph | Tibia BMD | tsk BMD (mg/cm2) | %Ca Abs | % Mg Abs. | % P Abs. | |
| A.5 | 7.1±0.2 | 169±4 | 224.5±5.7 | 76.2±1.0** | 60,1±2.0 | 77.8±3.7 |
| A.3 | 7.1±0.2 | 163±6 | 221.8±5.0 | 82.4±2.2 | 59,2±1.5 | 77.1±3.0 |
| GF.3 | 6.4±0.2*,** | 172±6** | 236.0±7.1*,** | 92.0±2.0*,** | 83,1±2.1*,** | 92.2±1.6*,** |
| No differences in pH, absorptions and BMD were observed at the beginning of the study. BW increases were not significantly different among groups. At t=f, GF.3 presented the lowest caecal pH and showed a significant increment of all studied parameters compared to A.3 (** P<0.05). G.3 also had higher tskBMD, and Ca, Mg, P Abs. than A.5 diet (* P<0.05). | ||||||
Conclusion: These results evidence the increment in Ca, Mg and P absorption percentage and suggest the benefic effect of GOS/FOS in bone health during normal growth. N.V.Nutricia. Grant of CONICET: PIP 002/2011.
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