Bone Abstracts

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The Wnt pathway engages both canonical and non-canonical signalling to accomplish a salutary benefit of increased bone mass, as evidenced by the presence of individuals with high bone mass, who exhibit specific functional variants in members of the pathway. This talk will highlight the importance of the influence on Wnt signalling being received by the bone in response to loading and the signals emanating from bone that influence overall metabolism and health in the whole anim...

Recent studies have demonstrated that activin signalling plays a crucial role in the skeleton. Activins control both osteoblast and osteoclast function and are present in the bone extracellular matrix. This makes activin signalling an important new therapeutic target for a dual anabolic antiresorptive intervention in osteoporosis.Activins belong to the large TGF-β superfamily that also includes BMPs, TGFβs and GDFs. Like other TGF-β member...