Bone Abstracts

Prostate cancer is a commonly diagnosed malignancy in Europe. Bone is one of the common metastasis sites. There is increasing evidence for estrogen involvement in the prostate tumorigenesis. ERβ knockout (BERKO) mice have been reported to have anti-proliferative, anti-inflammatory and potential anti-tumorigenic functions of ERβ. However, prostate phenotype of BERKO mice has been under debate.The potential effect of ERβ on prostate tumorgen...

: Glucocorticoid-induced osteoporosis (GIO) is the most frequent secondary osteoporosis in patients undergoing steroid therapy.Recently we demonstrated that the inhibition of bone formation in GIO is occurring in part via the suppression of autocrine cytokines by the glucocorticoid receptor (GR) monomer in osteoblasts (Cell Metab 11, 517–531). Since emerging evidences indicate that microRNAs (miRNAs) play a critical role in the differentiat...

Introduction:: The pharmacological glucocorticoids used have an anti-inflammatory and immunosuppressive action, but therapeutic gain is often accompanied by side effects. Widely prescribed, both by medical specialists and generalists, our work objective is to evaluate the perception by specialist medicine physicians of the impact of the discomfort caused by corticosteroid-induced adverse events.Methods:: We conducted a descriptive survey with 85 speciali...

Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily, which functions as bile acid sensor controlling the bile acid homeostasis. We have investigated the role of FXR in regulating bone metabolism in vivo. We have identified expression of FXR in calvaria and bone marrow cells, which was gradually increased during osteoblastic differentiation in vitro. Deletion of FXR in vivo has resulted in significant reduction in bone mineral density by...

Introduction: Previous studies demonstrated that estrogen deficit in female patients causes inflammatory periodontal diseases. Sex steroids act by interacting with intracellular receptors located in odontoblasts, osteoblasts, gingival fibroblasts, and periodontal ligament cells. Inflammation in periodontal tissue is caused by excessive concentration of sex hormone receptors in oral mucosa.Aim: Studying the influence of indole-3-carbinol (I3C) and epigall...