Bone Abstracts

Objectives: To find the predicting factors for bone density in premenopausal women.

Methods: Two hundred and forty-five premenopausal women without factors that can cause secondary osteoporosis were analyzed. Age, height, weight, change of height from peak height, history (Hx) of fracture, family Hx of hip or other fracture, Hx of estrogen use, calcium or vitamin D supplementation, smoking and previous Hx of amenorrhea more than 3 months were questioned. Lumbar, femur neck, and hip bone density were measured by dual energy bone absorptiometry. Data were analyzed by analysis of covariance and multiple regression analysis.

Results: Mean age of subjects was 43.6±3.7 years. Smoking women showed significantly lower lumbar spine bone density after adjustment of age and BMI (P=0.04). Women with Hx of fracture, family fracture, estrogen use, calcium and vitamine D supplementation, and amenorrhea didn’t show significantly different bone density. By multiple regression analysis, bone density of lumbar spine was determined by height, change of height from peak height, weight and smoking (r²=0.101, P=0.001). Bone density of femur neck was determined only by weight (r²=0.050, P=0.001), and that of hip was by weight and height (r²=0.088, P=0.001).

Conclusion: In premenopausal women, smoking affect only on lumbar spine bone density and predicting factors for bone density were height, change of height from peak height, weight and smoking in lumbar spine, weight in femur neck, and weight and height in hip.

Key words: Bone density, premenopausal women.