Bone Abstracts

Background: Recently, the prevalence of osteoporosis and sarcopenia in the elderly has dramatically increased. However the relationship between theses disease is not clear.

Object: We aimed to determine the independent relations of muscle mass to osteoporosis (femur neck) in relation to body weight, fat mass, and other confounders.

Design: We analyzed body composition and BMD data of 570 males and 734 females who are older than 65 years from KNHANES V(2010). Body composition and bone mineral density (BMD) of femur neck were measured by DXA. Sarcopenia was defined as the appendicular skeletal muscle mass (ASM) divided by height squared (Ht²) (kg/m²) of <−1 S.D. below the sex-specific mean for 20–39 years adults.

Results: ASM/(Ht)² and BMD were positive correlated with body fat mass/(Ht)². Protein and fat, carbohydrate, calcium, phosphate, calorie intake were also positive correlated with BMD. Exercise also had positive correlation with ASM/(Ht)² and BMD. However Vitamin D only positively related with ASM/(Ht)². With compounding factors adjusting, ASM/(Ht)² had also positive relation with BMS in men (R²=0.171, B=0.027, P<0.001) and in women (R²=0.226, B=0.016, P=0.002). The adjusted odds ratios (95% CIs) of osteoporosis in sarcopenia patients were 1.24 (95% CI 1.47–8.15) in men and not significant in women.

Conclusions: Bone mineral density were independently associated with muscle mass. And in men, sarcopenia was independent risk factor for oseoporosis in men but not women.