ECTS2013 Poster Presentations Calciotropic and phosphotropic hormones and mineral metabolism (33 abstracts)
Short-term resveratrol supplementation stimulates serum levels of bone-specific alkaline phosphatase in obese non-diabetic men
Morten Møller Poulsen 1 , Marie Juul Ornstrup 1 , Torben Harsløf 1 , Niels Jessen 1, , Bente Lomholt Langdahl 1 , Bjørn Richelsen 1 , Jens Otto Lunde Jørgensen 1 & Steen Bønløkke Pedersen 1
1Department of Endocrinology and Internal Medicine MEA, Aarhus University Hospital, Aarhus, Denmark; 2Department of Pharmacology, Aarhus University Hospital, Aarhus, Denmark.
Despite the substantial preclinical evidence for a positive effect of the polyphenolic compound resveratrol, human data are very scarce, and currently no clinical data addressing the potential impact on bone metabolism have been published. In the present study we addressed this issue by testing a panel of bone specific biomarkers in order to identify potential bone metabolic effects of resveratrol in human subjects. In a randomized, placebo-controlled, double-blinded and parallel-group design, 24 obese (BMI (kg/m2): 34.2±0.7) non-diabetic men were randomly assigned to 500 mg resveratrol or placebo treatment three times daily for four weeks. Biomarkers of bone metabolism, inflammatory parameters, circulating hormones and DXA scans were measured before and after the intervention period. Plasma levels of bone-specific alkaline phosphatase increased significantly in the resveratrol group as compared to placebo (delta changes (U/l); placebo: −1.7±0.7 vs resveratrol: 4.9±0.6; P<0.001). This was paralleled by a tendency of total alkaline phosphatase to rise within the resveratrol group (P=0.061), whereas no changes were detected in other biomarkers of bone metabolism, including PINP, osteocalcin, CTx, or PTH. We suggest that resveratrol represent a primary anabolic modality in preserving bone integrity by possible interference with the mineralization process. The clinical implications remain to be evaluated.
Article tools
My recent searches
My recently viewed abstracts
Authors
Bone Abstracts
ISSN 2052-1219 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more