ECTS2013 Poster Presentations Bone development/growth and fracture repair (40 abstracts)
Premixed calcium phosphate cement as a carrier for bone morphogenetic protein 2
Nick Walters 1 , Gry Hulsart-Billström 1 , Håkan Engqvist 2 & Sune Larsson 1
1Department of Orthopedics, Uppsala University, Uppsala, Sweden; 2Department of Materials in Medicine, Uppsala University, Uppsala, Sweden.
Introduction: A BMP-2-containing premixed calcium phosphate cement (PCPC) could potentially provide the surgeon with an easy-to-handle alloplastic material with osteoinductive properties, accelerating bone ingrowth by stimulating osteogenic differentiation.
Methods: The release profile of BMP-2 at 0.05 and 0.50 mg/ml from the PCPC was characterized over a period of 1 week using ELISA.
Results: The PCPC released BMP-2 in a biphasic manner, with an initial burst release upon the setting of the material followed by a gradual release. At the first hour was ~1.25% released from the 0.50 mg/ml cement and 0.35% from the 0.05 mg/ml cement. After 1 week was 1.5% of BMP-2 released from the 0.50 mg/ml cement and 0.75% from the 0.05 mg/ml.
Conclusion: This initial burst release could be beneficial by attracting MSCs to the material by chemotaxis. The subsequent gradual release should provide the tissue surrounding the cement with BMP-2, potentially resulting in osteoinduction by stimulating differentiation and activate material resorption by osteoclasts, improving integration of the material by bone-ingrowth.
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