ECTS2013 Poster Presentations Bone biomechanics and quality (28 abstracts)
Obesity induced by a sucrose-rich diet promotes deficits in bone mineralization and microarchitecture
Bruna Biffe 1 , Maria Tereza Nunes 2 , Antonio Augusto Carvalho 1 , Vilma Colli 1 , Rita Dornelles 1 , Ana Claudia Nakamune 1 , Pedro Florindo 1 & Mario Jefferson Louzada 1
1São Paulo State University – UNESP, Araçatuba, São Paulo, Brazil, 2University of São Paulo – USP, São Paulo, São Paulo, Brazil.
In order to examine metabolic and biophysical parameters arising from obesity, male rats were given to drinking 30% sucrose (p/v) for 8 weeks. During the experimental period, animals in the control group (C) consumed higher amounts of food and water, but the body mass was smaller than the group receiving sucrose (S). In this group, the caloric load given to the animals for eight weeks resulted in increased energy consumption, in glycemia and in plasma leptin and abdominal fat. However, did not alter the plasma concentration of insulin. The analysis of bone showed smaller bone density for the S group considering the comparison between their initial and final values. Moreover, the amount of bone mineral material was lower in animals in that group. Complementing these data, was found in group S smaller trabecular bone volume as percentage of tissue volume (BV/TV) and trabecular thickness (Tb.Th) resulting in increase intertrabecular space in the group that ingested 30% sucrose. Therefore, obesity induced by means of a sucrose-rich diet had a negative influence of bone mineralization and microarchitecture.
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Bone Abstracts
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