Bone Abstracts

Introduction: Rheumatoid arthritis is the most common inflammatory arthritis. It is also an autoimmune disease. It’s immunological profile is typical and often correlated with clinical presentation. If acticorps anti-CCP and rheumatoid factor are part of the diagnostic criteria. Anti-nuclear antibody are found in 15–40%.

Objectives: Studying the immunological profile in 110 patients treated for rheumatoid arthritis.

Materiels and methods: Study of 110 cases of RA (ARA and EULAR criteria) collected in the rheumatology department. The study of immunological profile, including rheumatoid factor (RF), anti-CCP antibody (ACPA) and antinuclear antibodies (ANA) were analyzed in all patients. Rheumatoid factor positive when >1/64 by agglutinin or 20 IU by ELISA method. AAN positif when >1/80. and ACPA considerated significativly positif when exced 50 IU.

Results: 110 patients were included. The mean age was 51 years. Patients were female predominantly (87.2%). Mean duration of rhumatisme arthritis was 8 years. Regarding the immunological profile, all patients had rheumatoid factor and antinuclear antibody, except two respectively. The antibody anti CCP were performed in 70% of patients. ANA were positive in 26% of cases. Rheumatoid factor positive in 73% of cases, and anti CCP Acts which were found in 77 cases were positives in 74% of patients. Among the patients with three parameters were made, 77 cases, all were positive in 11 cases (14.3%) and anti CCP Ab and rheumatoid factor positive in 32 cases (41.5%).

Conclusion: Our results were comparable to the literature. Rheumatoid arthritis is an inflammatory arthritis tropic genetic and immunological important. No only immunological parameters for the diagnostic criteria are present, but also anti-nuclear antibody.